Abstract：To evaluate adverse effects of triclocarban (TCC) on vertebrate neurobehavior and their mechanisms, we explored the larval neurodevelopmental toxicity under acute exposure and the adult nervous behavior under chronic exposure by employing zebrafish (Danio rerio) as the model vertebrate. The results show that the TCC acute exposure at the sublethal dose resulted in a decrease in both the autonomous movement activity and the sensitivity to sound and light stimulation of embryonic and larval zebrafish. As indicated by Acridine orange apoptotic staining that TCC induced excessive cell apoptosis in the larval head, kidney, brain and eyes. A series of malformation symptoms were observed with scanning electron microscopy, such as deformed lateral line nerve muzzle, inhibited development, reduced number of hair cell clusters and disordered arrangement. The group of adult zebrafish under the long-term TCC-exposure were observed to suffer from excessive anxiety and panic, decreased risk aversion and vigilance, as well as autism and reluctance to social activity. Overall, TCC exposure can significantly affect zebrafish memory, learning ability and cognitive function.
赵晨曦, 王杨, 钱秋慧, 闫瑾, 肖傲, 王学东, 王慧利. 三氯卡班环境暴露对斑马鱼神经行为的影响[J]. 中国环境科学, 2022, 42(1): 456-464.
ZHAO Chen-xi, WANG Yang, QIAN Qiu-hui, YAN Jin, XIAO Ao, WANG Xue-dong, WANG Hui-li. Effects of environmental exposure to triclocarban on the neurobehavior of zebrafish (Danio rerio). CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(1): 456-464.
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