PM2.5及其组分短期暴露对空腹血糖和血脂的影响

桑晨; 贺颖倩; 贾佳; 陈浩; 王敏珍

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中国环境科学 ›› 2025, Vol. 45 ›› Issue (2) : 1118-1126.

环境毒理与健康

PM_2.5及其组分短期暴露对空腹血糖和血脂的影响

桑晨¹, 贺颖倩², 贾佳¹, 陈浩¹, 王敏珍¹

作者信息 +

Effects of short-term exposure to PM_2.5 and its constituents on fasting plasms glucose and blood lipids

SANG Chen¹, HE Ying-qian², JIA Jia¹, CHEN Hao¹, WANG Min-zhen¹

Author information +

文章历史 +

摘要

为探究PM_2.5及其组分(SO₄^2-、NO₃^-、NH₄⁺、OM和BC)短期暴露对人群空腹血糖和血脂的影响,以“金昌队列”为研究平台,从中国大气成分近实时追踪数据集获取金昌市2011~2015年PM_2.5及组分日均浓度数据.通过将研究对象家庭住址经纬度信息与污染物数据匹配,以评估个体污染物暴露水平.采用广义估计方程分析PM_2.5及其组分短期暴露对糖脂指标的影响.运用广义相加混合模型绘制暴露-反应关系曲线,并进行分层分析.结果显示,PM_2.5及其组分(SO₄^2-、NO₃^-、NH₄⁺、OM和BC)对人群血糖和血脂水平的影响存在一定的滞后效应,随着PM_2.5、SO₄^2-、NO₃^-、NH₄⁺、OM浓度的升高,FPG、TC、HDL-C和LDL-C呈上升趋势,TG呈下降趋势.PM_2.5和SO₄^2-对男性人群的空腹血糖水平影响更显著;PM_2.5及其五种组分对女性、年龄³60岁、超重或肥胖、处于糖尿病前期及患高血压人群的血脂水平影响更显著.因此,PM_2.5及其组分的短期暴露与人群血糖和血脂水平异常相关,不同高风险人群需加强自我防护措施.

Abstract

The effects of PM_2.5 and its constituents (SO₄^2-, NO₃^-, NH₄⁺, OM, BC) on fasting blood glucose and lipid levels in the short-term were examined in the “Jinchang Cohort”. The daily average concentrations of PM_2.5 and its constituents from 2010to 2015 in Jinchang City were sourced from China's Near Real-Time Air Pollutants dataset. Individual exposure was determined by matching the study subjects' residential addresses with pollution data. Generalized estimating equations were used to analyze the short-term effects of PM_2.5 and its constituents on glucose and lipid indicators. Generalized additive mixed models were used to create exposure-response curves and perform stratified analyses. The findings showed that PM_2.5 and its constituents had delayed effects on blood glucose and lipid levels. Specifically, higher concentrations of PM_2.5, SO₄^2-, NO₃^-, NH₄⁺, and OM correlated with increased levels of FPG, TC, HDL-C, and LDL-C, while TG showed a decrease. PM_2.5 and SO₄^2- exhibited more pronounced effects on fasting blood glucose levels in males, whereas PM_2.5 and its five components had more significant impacts on lipid levels in females, individuals aged 60 years or older, those who are overweight or obese, individuals in prediabetic stages, and those with hypertension. Therefore, short-term exposure to PM_2.5 and its components correlates with abnormal blood glucose and lipid levels in the population. Thus, various high-risk groups should adopt self-protection measures accordingly.

导出引用

桑晨, 贺颖倩, 贾佳, 陈浩, 王敏珍. PM_2.5及其组分短期暴露对空腹血糖和血脂的影响[J]. 中国环境科学. 2025, 45(2): 1118-1126

SANG Chen, HE Ying-qian, JIA Jia, CHEN Hao, WANG Min-zhen. Effects of short-term exposure to PM_2.5 and its constituents on fasting plasms glucose and blood lipids[J]. China Environmental Science. 2025, 45(2): 1118-1126

中图分类号： X503

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