O3暴露与健康研究的文献计量学分析与演化趋势

孔少杰; 马静; 易洪涛

PDF(1710 KB)

中国环境科学 ›› 2026, Vol. 46 ›› Issue (2) : 1072-1083.

环境毒理与健康

O₃暴露与健康研究的文献计量学分析与演化趋势

孔少杰¹, 马静², 易洪涛¹

作者信息 +

Bibliometric analysis and evolutionary trend of researches on O₃ exposure and health

KONG Shao-jie¹, MA Jing², YI Hong-tao¹

Author information +

文章历史 +

摘要

为了系统地了解臭氧(O₃)的暴露与健康风险的研究现状及演化趋势,基于中国知网(CNKI)和Web of Science (WoS)核心合集数据库进行检索,利用R语言的Bibliometric功能对O₃暴露与健康相关中英文文献进行数据分析与挖掘,并结合绘图软件Origin和文献数据可视化CiteSpace软件对结果进行可视化分析,揭示该领域的研究发展路径.结果表明:O₃暴露与健康研究在2000~2025年间稳步增长,中英文文献各582和915篇,且经历了萌芽期(2000~2016年)和激增期(2017年至今)两个阶段.英文文献中各国家、机构和作者之间的合作比较紧密.英文研究趋势经历了技术积累与初步关注、暴露评估与健康影响的初步探索、长期暴露与健康研究的深入、健康负担评估与政策引导4个阶段.中文关键词主要集中在健康效应与影响、污染源与形成过程以及时空分布与变化3个方面,且经历了早期研究与暴露评价(2009~2015年)、污染源识别(2016~2020年)以及特定群体的风险与高科技手段的引入(2021~2025年)3个阶段的演变.

Abstract

To gain a more systematic understanding of the current status and evolving trends in O₃ exposure and health risk research, literature was retrieved from the CNKI and Web of Science (WoS) core collection databases. Bibliometric tools in R were used to analyze the Chinese and English literature related to O₃ exposure and health. The visualization software Origin and CiteSpace were then used to visualize the results, revealing the research development path in this field. The results showed that research on the health impacts of O₃ exposure increased steadily from 2000 to 2025, with 582 and 915 articles in Chinese and English literature, respectively. The research evolution comprised two phases: the budding phase (2000~2016) and the explosive phase (2017 to present). Collaboration among countries, institutions, and authors was relatively close in the English literature. The trends in English research progressed through four stages: technological accumulation and initial concern, exposure assessment and preliminary exploration of health effects, in-depth study of long-term exposure and health, and health burden assessment and policy guidance. Chinese keywords focused mainly on three aspects: health effects and impacts, pollution sources and formation processes, and temporal-spatial distribution and variation. Chinese literature evolved through three stages: early research and exposure assessment (2009~2015), identification of pollution sources (2016~2020), and the introduction of high-tech methods for risk assessment in specific groups (2021~2025).

导出引用

孔少杰, 马静, 易洪涛. O₃暴露与健康研究的文献计量学分析与演化趋势[J]. 中国环境科学. 2026, 46(2): 1072-1083

KONG Shao-jie, MA Jing, YI Hong-tao. Bibliometric analysis and evolutionary trend of researches on O₃ exposure and health[J]. China Environmental Science. 2026, 46(2): 1072-1083

中图分类号： X515

参考文献

[1] Li K, Jacob D J, Liao H, et al. A two-pollutant strategy for improving ozone and particulate air quality in China [J]. Nat Geosci, 2019, 12(11):906-910.
[2] Liu H, Liu S, Xue B, et al. Ground level ozone pollution and its health impacts in China [J]. Atmospheric Environment, 2018,173:223-230.
[3] Lu X, Hong J, Zhang L, et al. Severe surface ozone pollution in China: A global perspective [J]. Environmental Science and Technology Letters, 2018,5(8):487-494.
[4] Dearborn L C, Hazlehurst M F, Sherris A R, et al. Early-life ozone exposure and asthma and wheeze in children [J]. JAMA Network Open, 2025,8(4):e254121.
[5] 夏永杰,周璐,牛越,等.2020年中国大气臭氧对慢性阻塞性肺病死亡影响的疾病负担分析和健康经济学评价[J].环境科学研究, 2023,36(2):237-245. Xia Y J, Zhou L, Niu Y, et al. COPD mortality burden and related health economic assessment associated related with to ambient ozone in 2020 in China [J]. Research of Environmental Sciences, 2023,36(2): 237-245.
[6] 姜云星,白丽君,吴少伟.臭氧短期暴露对人群心血管健康及相关表观遗传标志物的影响[J].兰州大学学报(医学版), 2025,51(1): 12-25. Jiang Y X, Bai L J, Wu S W. Progress in research into the effects of short-term ozone exposure on cardiovascular health and related epigenetic markers in the population [J]. Journal of Lanzhou University (Medical Sciences), 2025,51(1):12-25.
[7] 贾云飞,陈春静,王恒学,等.南京市大气PM₁₀短期暴露对心血管疾病死亡的影响[J].环境与职业医学, 2020,37(8):753-758. Jia Y F, Chen C J, Wang H X, et al. Effect of short-term exposure to PM₁₀on mortality of cardiovascular diseases in Nanjing [J]. Journal of Environmental and Occupational Medicine, 2020,37(8):753-758.
[8] 方欣怡,陈仁杰,阚海东,等.臭氧暴露对哮喘的影响及作用机制[J].上海预防医学, 2024,36(3):303-310. Fang X Y, Chen R J, Kan H D, et al. The effect of ozone exposure on asthma and the potential mechanisms [J]. Shanghai Journal of Preventive Medicine, 2024,36(3):303-310.
[9] 陈嘉惠,胡大宇,贾旭,等.大气臭氧短期监测指标与健康年轻人肺功能和气道炎症的关联[J].北京大学学报(医学版), 2020,52(3): 492-499. Chen J H, Hu D Y, Jia X, et al. Monitoring metrics for short-term exposure to ambient ozone and pulmonary function and airway inflammation in healthy young adults [J]. Journal of Peking University(Health Sciences), 2020,52(3):492-499.
[10] 谢晓栋,胡建林,张远航.我国臭氧污染研究热点与趋势的文献计量分析[J].中国环境科学, 2024,44(12):6513-6521. Xie X D, Hu J L, Zhang Y H. Research topic and trend analysis of ozone pollution in China based on bibliometric review [J]. China Environmental Science, 2024,44(12):6513-6521.
[11] 张家韬.基于出生队列的大气臭氧短期暴露与婴幼儿哮喘/喘息的关联性研究[D].济南:山东大学, 2024. Zhang J T. The association between short-term exposure to ambient ozone and infant asthma/wheezing, based on a birth cohort [D]. Jinan: Shandong University, 2024.
[12] 黄忠国,杨丽莉,卓煜琳,等.气温长期暴露与中老年人心血管代谢性疾病共病发生发展关联的队列研究[J].中国慢性病预防与控制, 2025,33(4):247-253,259. Huang Z G, Yang L L, Zhuo Y L, et al. A cohort study on the correlation between long-term temperature exposure and the development and progression of cardio-metabolic diseases comorbidities in the middle-aged and old populations [J]. Chinese Journal of Prevention and Control of Chronic Diseases, 2025,33(4): 247-253,259.
[13] 李燃,夏依章,张艳,等.2020年成渝地区大气污染所致老年人群健康风险评估及预测分析[J].中国医药导报, 2023,20(14):159- 162. Li R, Xia Y Z, Zhang Y, et al. Health risk assessment and prediction analysis of elderly population caused by air pollution in Chengdu-Chongqing area in 2020[J]. China Medical Herald, 2023, 20(14):159-162.
[14] 孔少杰,易洪涛.基于文献计量学的减污降碳政策研究进展与展望[J].环境科学研究, 2025,38(2):231-242. Kong S J, Yi H T, Research progress and prospects of pollution reduction and carbon emission mitigation policies: A bibliometric analysis [J]. Research of Environmental Sciences, 2025,38(2):231- 242.
[15] Sun H Z, Daalen K R V, Morawska L, et al. An estimate of global cardiovascular mortality burden attributable to ambient ozone exposure reveals urban-rural environmental injustice [J]. One Earth, 2024,7(10):1803-1819.
[16] Sun H Z, Zhao J C, Liu X, et al. Antagonism between ambient ozone increase and urbanization-oriented population migration on Chinese cardiopulmonary mortality [J]. Innovation, 2023,4(6):100517.
[17] Zhang J Y, Ai B Z, Guo Y M, et al. Long-term exposure to ambient ozone and adult-onset asthma: A prospective cohort study [J]. Environmental Research, 2024,252(2):118962.
[18] Zhang Z L, Wang C Q, Lin C Y, et al. Association of long-term exposure to ozone with cardiovascular mortality and its metabolic mediators: Evidence from a nationwide, population-based, prospective cohort study [J]. The Lancet Regional Health-Western Pacific, 2024, 52:101222.
[19] Zhao K, He F F, Zhang B Y, et al. Short-term ozone exposure on stroke mortality and mitigation by greenness in rural and urban areas of Shandong province, China [J]. BMC Public Health, 2024,24(1): 2955.
[20] Cox R M. The use of passive sampling to monitor forest exposure to O₃, NO₂ and SO₂: A review and some case studies [J]. Environmental Pollution, 2003,126(3):301-311.
[21] Handley T, Grulke N E. Interactive effects of O₃ exposure on California black oak (Quercus kelloggii Newb.) seedlings with and without N amendment [J]. Environmental Pollution, 2008,156(1):53- 60.
[22] Geels C, Andersson C, Hänninen O, et al. Future premature mortality due to O₃, secondary inorganic aerosols and primary PM in Europe- sensitivity to changes in climate, anthropogenic emissions, population and building stock [J]. International Journal of Environmental Research and Public Health, 2015,12(3):2837-2869.
[23] Sticozzi C, Pecorelli A, Romani A, et al. Tropospheric ozone affects SRB1levels via oxidative post-translational modifications in lung cells [J]. Free Radical Biology and Medicine, 2018,126:287-295.
[24] Kaplan G G, Tanyingoh D, Dixon E, et al. Ambient ozone concentrations and the risk of perforated and nonperforated appendicitis: A multicity case-crossover study [J]. Publication: Environmental Health Perspectives, 2013,121(8):939-943.
[25] Tang W L, Yu M, Bai G X, et al. Ambient ozone and mortality from respiratory diseases: A nationwide analysis in China [J]. Global Transitions, 2024,6:113-122.
[26] Bravo M A, Fang F, Hancock D B, et al. Long-term air pollution exposure and markers of cardiometabolic health in the national longitudinal study of adolescent to adult health (Add Health) [J]. Environment International, 2023,177:107987.
[27] 廖志恒,范绍佳.2006~2012年珠江三角洲地区O₃污染对人群健康的影响[J].中国环境科学, 2015,35(3):897-905. Liao Z H, Fan S J. Human health impact of exposure to ozone pollutant in Pearl River Delta region during 2006~2012[J]. China Environmental Science, 2015,35(3):897-905.
[28] 班婕,李湉湉.北京市不同度量方式下臭氧短期暴露人群急性健康效应研究[J].环境与健康杂志, 2016,33(4):287-291. Ban J, Li T T. Short-term effects of different ozone metrics on daily mortality in Beijing [J]. Journal of Environment and Health, 2016,33(4):287-291.
[29] 陈仁杰,陈秉衡,阚海东.上海市近地面臭氧污染的健康影响评价[J].中国环境科学, 2010,30(5):603-608. Chen R J, Chen B H, Kan H D. Health impact assessment of surface ozone pollution in Shanghai [J]. China Environmental Science, 2010, 30(5):603-608.
[30] 孙岩岩,黄婧,赵岩,等.室内臭氧对循环系统炎症因子EGF及Fractalkine的影响—随机双盲交叉试验[J].中国循证心血管医学杂志, 2020,12(5):550-553. Sun Y Y, Huang J, Zhao Y, et al. Effects of indoor ozone on inflammatory factors EGF and Fractalkine in circulatory system [J]. Chinese Journal of Evidence-Based Cardiovascular Medicine, 2020, 12(5):550-553.
[31] 陈远翔,修光利,杨军,等.城市轨道交通地下车站环境健康风险因子及相关标准的研究进展[J].环境与健康杂志, 2012,29(12):1139- 1148. Chen Y X, Xiu G L, Yang J, et al. Environmental health risk factors and related standards for urban mass transit underground stations: A review of recent studies [J]. Journal of Environment and Health, 2012,29(12):1139-1148.
[32] 张宏,董继元,王建军,等.兰州市臭氧对儿童哮喘的短期影响及其季节性差异[J].北京大学学报(医学版), 2022,54(2):227-235. Zhang H, Dong J Y, Wang J J, et al. Short-term effects and seasonal variation of ozone on daily hospital outpatient visits for childhood asthma in Lanzhou [J]. Journal of Peking University(Health Sciences), 2022,54(2):227-235.
[33] 孔少杰,易洪涛.中国O₃暴露与健康风险时空演变及不平等的双维分区管控[J].中国环境科学, 2025,45(10):5873-5884. Kong S J, Yi H T. Spatialtemporal evolution of O₃ exposure and health risks and unequal two-dimensional zoning control in China [J]. China Environmental Science, 2025,45(10):5873-5884.
[34] 陈瑞,杨永宏,魏巧珍,等.2014~2022年兰州市大气O₃-8h浓度对居民急救的影响[J].环境卫生学杂志, 2025,15(3):229-235,239. Chen R, Yang Y H, Wei Q Z, et al. Analysis of the impact of atmospheric O₃-8h concentration on resident emergency admissions in Lanzhou city, China, 2014~2022[J]. Journal of Environmental Hygiene, 2025,15(3):229-235,239.
[35] 刘晓慧,曹寒,张晗,等.大气臭氧长期暴露对社区自然人群抑郁、焦虑和压力状况的影响[J].医学新知, 2021,31(1):5-13. Liu X H, Cao H, Zhang H, et al. Effects of long-term exposure to atmospheric ozone on depressive, anxiety and stress symptoms of natural population in the community [J]. New Medicine, 2021, 31(1):5-13.
[36] 张丽,张晓飞,石国秀,等.宁波市O₃与气象因素短期暴露对死亡人数的影响及交互作用[J].中华疾病控制杂志, 2023,27(5):522- 527,539. Zhang L, Zhang X F, Shi G X, et al. Effects and interactions of short-term exposure to O₃ and meteorological factors on the number of deaths in Ningbo city [J]. Chinese Journal of Disease Control and Prevention, 2023,27(5):522-527,539.
[37] 郑向东,韦小丽.中国4个地点地基与卫星臭氧总量长期观测比较[J].应用气象学报, 2010,21(1):1-10. Zheng X D, Wei X L. Long-term total ozone comparisons between space-based and ground-based observations at 4sites in China [J]. Journal of Applied Meteorological Science, 2010,21(1):1-10.
[38] 骆雨茜,陈静,郝宇杭,等.2015~2022年重庆市近地面臭氧的暴露风险及环境影响[J].中国环境科学, 2024,44(5):2754-2765. Luo Y Q, Chen J, Hao Y H, et al. Exposure risk assessments and environmental impacts of surface ozone in Chongqing during 2015~2022[J]. China Environmental Science, 2024,44(5):2754-2765.
[39] 程育恺,戴海夏,张蕴晖,等.长三角地区2017~2020年臭氧浓度时空分布与人群健康效益评估[J].环境科学, 2023,44(2):719-729. Cheng Y K, Dai H X, Zhang Y H, et al. Spatial and temporal distribution characteristics of ozone concentration and population health benefit assessment in the Yangtze River Delta region from 2017 to 2020[J]. Environmental Science, 2023,44(2):719-729.
[40] Fenech S, Doherty R M, Heaviside C, et al. The influence of model spatial resolution on simulated ozone and fine particulate matter for Europe: Implications for health impact assessments [J]. Atmospheric Chemistry and Physics, 2018,18(8):5765-5784.
[41] Andrea L, Pineda R. Simple atmospheric dispersion model to estimate hourly ground-level nitrogen dioxide and ozone concentrations at urban scale [J]. Environmental Modelling and Software, 2014,59:127- 134.
[42] Fang M, Jiang C Z, Yuan Z, et al. The interaction of ambient ozone and personal temperature variability on blood markers of inflammation, oxidative stress, coagulation, endothelial function, and stress hormones [J]. Atmospheric Environment, 2024,338:120818.
[43] Viebahn H R, León O S. Ozone in medicine. The low-dose ozone concept and its basic biochemical mechanisms of action in chronic inflammatory diseases [J]. International Journal of Molecular Sciences, 2021,22(15):7890.
[44] Xu K, Yao Y, Liu H J, et al. ITGB4deficiency induces DNA damage by downregulating HDAC1in airway epithelial cells under stress stimulation [J]. Pediatric Allergy and Immunology, 2022,33(10): e13871.
[45] 陈浪,赵川,关茗洋,等.我国大气臭氧污染现状及人群健康影响[J].环境与职业医学, 2017,34(11):1025-1030. Chen L, Zhao C, Guan M Y, et al. Ozone pollution in China and its adverse health effects [J]. Journal of Environmental and Occupational Medicine, 2017,34(11):1025-1030.
[46] Kadiiska M B, Basu S, Brot N, et al. Biomarkers of oxidative stress study V: Ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine [J]. Free Radical Biology & Medicine, 2013,61:408-415.
[47] Sunil V R, Patel-Vayas K, Shen J L, et al. Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress [J]. Toxicology and Applied Pharmacology, 2012,263(2):195- 202.
[48] Yang C, Wang W Z, Wang Y Y, et al. Ambient ozone pollution and prevalence of chronic kidney disease: A nationwide study based on the China national survey of chronic kidney disease [J]. Chemosphere, 2022,306:135603.
[49] 李安琪,李娜,李韵谱,等.中国4个城市大气臭氧对呼吸系统疾病住院人数影响的时间序列分析[J].地球环境学报, 2024,15(3): 514-525. Li A Q, Li N, Li Y P, et al. A time-series analysis of the effect of atmospheric ozone on hospitalization of residents with respiratory diseases in four Chinese cities [J]. Journal of Earth Environment, 2024, 15(3):514-525.
[50] Liang S R, Chen Y M, Sun X L, et al. Long-term exposure to ambient ozone and cardiovascular diseases: Evidence from two national cohort studies in China [J]. Journal of Advanced Research, 2024,62:165-173.
[51] Levi A, Carasso Romano G H, Barnett-Itzhaki Z. Ground-level ozone exposure and type 2diabetes incidence: An ecological study of environmental and social determinants [J]. Atmosphere, 2025,16(5): 528.
[52] Dimakopoulou K, Douros J, Samoli E, et al. Long-term exposure to ozone and children's respiratory health: Results from the RESPOZE study [J]. Environmental Research, 2020,182:109002.
[53] Clayton C J, Turnock S T, Marsh D R, et al. Reducing inequities in the future air pollution health burden over Europe [J]. Earth's Future, 2025,13(5):e2024EF005404.
[54] Yang J, Ju Q Y, Chen S F, et al. Spatiotemporal evolution of regional air pollution exposure and health effects assessment in Jiangsu province, China [J]. Atmosphere, 2025,16(4):446.
[55] 刘静怡,孟聪申,韩京秀.1990~2019年全球环境危险因素疾病负担—GBD2019数据再分析[J].环境卫生学杂志, 2023,13(3):170-176. Liu J Y, Meng C S, Han J X. Global disease burden due to environmental risk factors in 1990~2019: A reanalysis of GBD 2019 data [J]. Journal of Environmental Hygiene, 2023,13(3):170-176.
[56] WHO. Health risks of air pollution in Europe-HRAPIE project. New emerging risks to health from air pollution-results from the survey of experts. World Health Organization, 2013.
[57] 杨昆鹏,刘浩然,邢成志,等.基于TROPOMI观测的珠三角地区对流层臭氧特征研究[J].大气与环境光学学报, 2025,20(1):47-59. Yang K P, Liu H R, Xing C Z, et al. Analysis of tropospheric ozone characterization in Pearl River Delta region based on TROPOMI [J]. Journal of Atmospheric and Environmental Optics, 2025,20(1):47-59.
[58] 何超.中国地表臭氧污染水平、风险与暴露不平等的时空格局研究[D].武汉:武汉大学, 2021. He C. Research on the spatialtemporal pattern of surface ozone pollution level, risk and exposure inequality in China [D]. Wuhan: Wuhan University, 2021.
[59] 赵楠,卢毅敏.中国地表臭氧浓度估算及健康影响评估[J].环境科学, 2022,43(3):1235-1245. Zhao N, Lu Y M. Estimation of surface ozone concentration and health impact assessment in China [J]. Environmental Science, 2022,43(3): 1235-1245.
[60] Lefohn A S, Foley J K. Establishing relevant ozone standards to protect vegetation and human health-exposure dose-response considerations [J]. Journal of the Air & Waste Management Association, 1993,43(1):106-112.
[61] Tagliaferro S, Maio S, Pirona F, et al. Assessing external exposome by implementing an environmental data management system using open data [J]. Scientific Reports, 2024,14(1):1-14.
[62] Morantes G, Lara-Ibeas I, Molina C, et al. Harm from indoor air contaminants in offices [J]. Building and Environment, 2025,284: 113365.