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| Effects of sub-chronic samarium exposure on ultra-structure of mice testis |
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Abstract In order to evaluate the sub-chronic toxicity of rare earth element samarium on testis of male mice, the mice were randomly selected and exposed to drinking water containing 0, 5, 50, 500, 2000mg/L of samarium nitrate for 90d. At the end of treatment, the mice were weighed and euthanized, and the organ coefficients were determined.The histopathology and electron microscopy observations were evaluated as well. Compared with the control group, the organ coefficient of testis from 2000mg/L group was significantly decreased;the seminiferous tubule of testis from high dose showed increased atrophies, vacuolation, and the germ cell count showed an obvious decrease and displayed disorderly organization.Electron microscopy observation showed that tubular membrane with higher dose was impaired, mitochondria were substantially swelled and vacuolated, nucleus membrane showed blur or was missing, and chromatin was marginated. Results indicated that under sub-chronic exposure of samarium with concentrations of 500mg/L and 2000mg/L, samarium exerted some damaging effect on mice testis.
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Received: 01 March 2011
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