|
|
Effects of butylbenzyl phthalate on learning and memory in mice. |
|
|
Abstract To investigate the oxidative damage of brain and the effects on learning and memory ability induced by butylbenzyl phthalate (BBP) in mice. Twenty-four male Kun Ming (KM) mice were randomly assigned into 4 groups (n=6), exposed to different concentrations of BBP (0, 50, 250 and 1250 mg/kg) by oral gavage for fourteen days. During the exposure period, the Morris water maze was used to test the learning and memory abilities. After Morris water maze test the experimental animals were ended lives, and then the reactive oxygen species (ROS) level, malondialdehyde (MDA) and glutathione (GSH) contents of brains, liver and kidney were measured. BBP caused significant differences in the abilities of learning and memory at 1250mg/kg by the Morris water maze (P<0.05). Along with the increase of BBP concentrations, increased ROS level, MDA content, and reduced GSH content were observed. BBP could induce oxidative damage in brains, liver and kidney of mice, and have negative effects on the abilities of learning and memory.
|
Received: 18 October 2012
|
|
|
|
|
|
|