人体及生物体内人工合成麝香的全球分布特征

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Abstract The distribution patterns of various synthetic musks in humans and organisms around the world are summarized and the associated bioaccumulation and toxicity are discussed. Galaxolide (HHCB), tonalide (AHTN), musk xylene (MX) and musk ketone (MK) often have the highest detection frequencies in all organisms (HHCB:20~100%; AHTN:7~100%; MX:6~95%; MK:3~98%) while other synthetic musks such as cashmeran (DPMI), celestolide (ADBI), phantolide (AHMI), traseolide (ATII), musk moskene (MM), musk tibetene (MT) and musk ambrette (MA) have lower detection frequencies and concentrations. Being the most representative synthetic musks in humans and other organisms, the levels of HHCB and AHTN were consistent with their use patterns. The lipid-weight based bioaccumulation factor (BAFL) varied greatly among different species in different regions, caused by different metabolisms and tissue sampled. Meanwhile, synthetic musks could impose inhibitory effects on the growth and development of organisms, have acute toxicity in the early life of fish and produce synergic toxicity in the presence of multiple contaminants. Future studies might focus on the evaluation of long-term toxicity and combined exposures to these low-concentration synthetic musks on organisms. More attention should be also taken on the toxicity of metabolites. Furthermore, it is necessary to develop the relevant environmental criteria or ecological risk thresholds.

Key words： human body living organisms synthetic musks global distribution

Received: 16 January 2023

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X503

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	LI Dan-yang
	WU Ying-xin
	WANG Tao
	ZOU Hong-yan

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LI Dan-yang,WU Ying-xin,WANG Tao等. Global distribution of synthetic musks in organisms and human bodies[J]. CHINA ENVIRONMENTAL SCIENCECE, 2023, 43(8): 4267-4279.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2023/V43/I8/4267

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