生物信息辅助斑马鱼模型揭示EHDPP诱发代谢疾病的机制

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Abstract This study utilized data mining from public databases, such as CTD and GEO, to demonstrate that EHDPP has the risk of inducing metabolic diseases by modulating various cell membrane receptor-mediated biological signaling pathways, which are related to the development of metabolic disorders and inflammation. Then, zebrafish larvae were utilized as models and exposed to a sublethal dose of EHDPP in order to validate the aforementioned findings. The findings revealed that after 5days of 500μg/L-EHDPP exposure, the content of triglycerides and total cholesterol in zebrafish larvae increased by 53.8% and 32.1%, respectively. Additionally, qRT-PCR results indicated that the lipid metabolism pathway mediated by Pparγ may serve as a potential pivotal mechanism for the induction of abnormal lipid accumulation in zebrafish caused by EHDPP.

Key words： 2-ethylhexyl diphenyl phosphate obesity metabolic disease bioinformatics analysis zebrafish

Received: 31 January 2023

PACS:

X174

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	Articles by authors
	NI An-yu
	LI Jin-yun
	FANG Lu
	WAN Ke-wei
	CHEN Yang
	WANG Hui-li
	YAN Jin

Cite this article:

NI An-yu,LI Jin-yun,FANG Lu等. Bioinformatics-assisted zebrafish model reveals the mechanism of EHDPP-induced metabolic disease[J]. CHINA ENVIRONMENTAL SCIENCECE, 2023, 43(9): 4942-4950.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2023/V43/I9/4942

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