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| The migration, transformation and toxicity of per- and polyfluoroalkyl substances in organisms |
| HAN Miao, LI Ze-kai, XU Lin, LI Zhao-yan, WEN Xin-yu, SHI Qing, HU Xiao-jie, QIN Chao, GAO Yan-zheng |
| Institute of Organic Contaminant Control and Soil Remediation, Nanjing Agricultural University, Nanjing 210095, China |
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Abstract This paper summarizes the sources of per- and polyfluoroalkyl substances (PFASs), focuses on the migration and transformation behaviour of PFASs in organisms and the main factors, and provides a hotspot analysis of the toxicity of PFASs in the last 38years of research using bibliometric methods. The results showed that the structure of PFASs, the enzyme activity in and protein content in biological tissues, and the content of organic matter in the environment are closely related to the migration and enrichment ability of PFASs in organisms. The studies on the toxicity of PFASs mainly focused on the toxic effect differences between different environmental media and organs, and the direction of the studies changed from the toxicity evaluation of plants and animals to the prediction of human health risks. On this basis, the toxic effects of PFASs were summarized at the individual, organ, biochemical and molecular levels, and it was suggested that the study of multilevel toxicity of PFASs is the future development trend, especially the use of quantitative conformational relationships to elucidate the hierarchical effects of biotoxicity is one of the approaches worth advocating. Finally, the present paper looks forward to the future development of the research on PFASs, which will provide new ideas for elucidating the environmental behaviour of new pollutants and carrying out related toxicological studies.
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Received: 11 September 2023
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Corresponding Authors:
秦超,副教授,qinchao@njau.edu.cn
E-mail: qinchao@njau.edu.cn
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