阿奇霉素急性暴露对斑马鱼幼鱼的毒性效应

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Abstract In this study, zebrafish served as a model organism to meticulously investigate the toxicological effects of azithromycin (AZM) on larval development during acute exposure. Our research delineated several distinct pathological changes in the larvae, including spinal curvature, incomplete swim bladder development, and the formation of yolk cysts. Notably, profound neurological impacts were also observed, characterized by a significant reduction in the number of neurons within the zebrafish brain, diminished AChE activity, and disruptions in light-dark rhythms. Further investigation using the PharmMapper website identified potential AZM target genes. Subsequent GO and KEGG enrichment analysis unveiled the potential influence of AZM on zebrafish vascular and immune systems. Experimental validation substantiated these predictions, demonstrating that AZM exposure induces abnormal vascular branching and dysfunction in the immune system of zebrafish larvae.

Key words： azithromycin neurotoxicity vascular toxicity immunotoxicity zebrafish

Received: 18 July 2023

PACS:

X503.225

Corresponding Authors: 钱秋慧,讲师,qhqian@usts.edu.cn E-mail: qhqian@usts.edu.cn

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	Articles by authors
	PU Qian
	ZHANG Shang-yi
	CHEN Chen
	LIU Xing-cheng
	WANG Hui-li
	QIAN Qiu-hui

Cite this article:

PU Qian,ZHANG Shang-yi,CHEN Chen等. Toxic effects of acute exposure to azithromycin in zebrafish larvae[J]. CHINA ENVIRONMENTAL SCIENCECE, 2024, 44(3): 1671-1678.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2024/V44/I3/1671

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