双酚S和双酚F诱导斑马鱼的神经发育毒性及联合作用分析

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Abstract In this research, BPS and BPF with sublethal dose were selected to compare the difference and combined toxicity of neurodevelopmental toxicity in zebrafish from four aspects: developmental phenotype, motor behavior, vascular development and neurotoxicity. The results showed that both BPS and BPF of LC5 induced apparent deformities in zebrafish, such as inhibiting the development of swimming sac and yolk sac. Exposure to BPS and BPF can affect the early motor behavior of zebrafish, which is potentially associated with damage to the cardiovascular system and nervous central system. BPS and BPF caused abnormal cardiovascular development and shortened caudal vein (CV) width in zebrafish. The abnormal transmission of DA, AChE and NO neurotransmitters leads to the impaired development of zebrafish neurons, which has a direct impact on the function of the lateral nervous system, and then leads to the impaired early motor behavior of zebrafish. BPS and BPF show different toxicity differences in specific indicators. BPF exposure is more likely to induce tissue and organ toxicity in zebrafish, while the direct toxicity of BPS is less than that of BPF, which is more manifested at the molecular level, indicating that there is a certain degree of difference in the mode of action of the two. In addition, combined with the analysis of the combined action of concentration addition model, the addition action between BPS and BPF is mainly. The results of this study provide a reference for health risk assessment and risk warning after exposure to BPS, BPF and their mixtures.

Key words： bisphenol F bisphenol S neurotoxicity combined exposure concentration addition model

Received: 17 July 2024

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X503

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	YANG Xiao
	BAO Zhi-wei
	HAN Xiao-wen
	SU Xin-cong
	MENG Ling-hao
	DAI Zhuo-ya
	WANG Ze-jun
	WANG Hui-li

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YANG Xiao,BAO Zhi-wei,HAN Xiao-wen等. Neurodevelopmental toxicity and combined effects of bisphenol S and bisphenol F induced zebrafish[J]. CHINA ENVIRONMENTAL SCIENCECE, 2025, 45(2): 1088-1098.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2025/V45/I2/1088

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