The short-term effects of NO2 on blood pressure and pulse pressure in patients with hypertension

SHI Qin; ZHENG Shan; ZHU Wen-zhi; WANG Min-zhen; MIAO Qian; LUO Yan; NIE Yong-hong; WENG Jun; LI Hai-yan; BAI Ya-na

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China Environmental Science ›› 2020, Vol. 40 ›› Issue (8) : 3627-3635.

Environmental Toxicology

The short-term effects of NO₂ on blood pressure and pulse pressure in patients with hypertension

SHI Qin¹, ZHENG Shan¹, ZHU Wen-zhi¹, WANG Min-zhen¹, MIAO Qian¹, LUO Yan¹, NIE Yong-hong², WENG Jun¹, LI Hai-yan², BAI Ya-na¹

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Abstract

In order to explore the short-term effects of gaseous pollutants (NO₂) on blood pressure (BP) and pulse pressure (PP) in patients with hypertension, the NO₂ monitoring data and meteorological observation data were collected from January 1, 2011 to November 30, 2015 in Jinchang, Gansu Province. After controlling the random effect and other confounding factors, a mixed-effect model was used to analyze the association between NO₂ and BP and PP in hypertensive patients based on a prospective cohort study. The results showed that: (1) An interquartile range (IQR) increase in NO₂ at lag 1day was associated with a 0.457mmHg (95%CI: 0.131~0.784) increase in systolic blood pressure (SBP); with each IQR increase of NO₂, diastolic blood pressure (DBP) at lag 7 day and pulse pressure (PP) at lag 4 day increased 0.276mmHg (95%CI:0.025~0.527) and 0.402mmHg (95%CI:0.047~0.758), respectively. All the results was statistically significant. (2) Gender, age, BMI, smoking, drinking, and season may modify the effects of NO₂ on BP and PP among hypertensive patients. The effects of NO₂ on BP and PP remained consistent with the results in the multi-pollutant model or after adjusting dust weather.

Key words

hypertensive patients / Jinchang cohort / mixed-effect model / NO₂

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SHI Qin, ZHENG Shan, ZHU Wen-zhi, WANG Min-zhen, MIAO Qian, LUO Yan, NIE Yong-hong, WENG Jun, LI Hai-yan, BAI Ya-na. The short-term effects of NO₂ on blood pressure and pulse pressure in patients with hypertension[J]. China Environmental Science. 2020, 40(8): 3627-3635

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