邻苯二甲酸二异癸酯对小鼠学习记忆的影响

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Abstract To elucidate the effect of di-iso-decyl phthalate (DIDP) on the learning and memory ability of mice, 42male Kunming mice were divided into 6groups randomly with 7mice in each group, including saline control group, the experimental groups of DIDP (1.5, 15, 150mg/(kg·d)), 20mg/(kg·d) Res control group, using as an anti-oxidant, 150mg/(kg·d) DIDP+20mg/(kg·d) Res group. During the constant exposure for 9days, the Morris water maze was used to test the abilities of learning and memory of mice. Reactive oxygen species (ROS), glutathione (GSH), malonaldehyde (MDA), 8-hydroxy-2deoxyguanosine (8-OHdG), tumor necrosis factor alpha (TNF-α) and interleukin-1beta (IL-1β) levels in the brain of mice were measured after their sacrifice. H&E-stained slices of hippocampus in brain tissue were applied to observe histopathological changes. The results indicated that the learning and memory ability of the 15、150mg/(kg·d) DIDP groups were significantly lower than the control group, while decreased significantly with the increase of DIDP concentrations. The 15, 150mg/(kg·d) DIDP could also induce oxidative stress in brain tissue and promote the release of inflammatory factors, while some of these effects were blocked by the administration of Res. Thus, it is concluded that DIDP-induced decrease of learning and memory ability in mice may be related to oxidative damage in brain tissue, while Res contributes to reduce the learning and memory damage in mice caused by DIDP effectively.

Key words： Di-iso-decyl phthalate (DIDP) learning and memory oxidative damage resveratrol (Res) Morris water maze

Received: 01 June 2017

PACS:

X503.22

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	Articles by authors
	LU Yu
	LI Yao
	HU Ying-dan
	LI Qiu-lin
	Zhao Yun
	ZOU Jian
	LIU Xiao-tong
	YANG Xu
	LI Rui

Cite this article:

LU Yu,LI Yao,HU Ying-dan等. Effects of Di-iso-decyl phthalate on the learning-memory ability in mice[J]. CHINA ENVIRONMENTAL SCIENCECE, 2018, 38(1): 361-368.

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http://manu36.magtech.com.cn/Jweb_zghjkx/EN/ OR http://manu36.magtech.com.cn/Jweb_zghjkx/EN/Y2018/V38/I1/361

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