This paper took the high-density residential area in Jiefangxi Basin of Jin'an District, Fuzhou City, Fujian Province, China, as an example. The PCSWMM model for storm water simulation was applied to the study area under different rainfall return periods, rainfall durations and rain peak coefficients, and the low impact development module in this model was used to study the flood control effects of seven different LID layout scenarios on the waterlogged nodes. The simulations yielded the following results. Under different rainfall conditions, the flood situation of waterlogged node in the worst affected area has been effectively controlled using single LID or combined LID layouts. The peak flow, ponding time and ponding depth decreased. The peak suspended sediment concentration of the node in vegetative swale layout and the combination layout of vegetative swale and green roof were higher than current land layout scenario, and in other layouts were under control. The reduction effects of different LID layouts were more significant under longer rainfall durations or lower rainfall return periods. Permeable pavement was the best choice in single LID layout, and the combination of permeable pavement and vegetative swale and green roof was the best choice in combined LID layouts. The research results can provide technical support for the Sponge City construction of urban residential area in the south of China, and provide reference and suggestions for local government to establish relevant codes and standards.