Anaerobic granular sludge bed membrane bioreactor (AnGMBR) with simulated domestic wastewater was studied at room temperature. With the influent COD of 260mg/L, the effluent COD of AnGMBR could remain stable under 30mg/L; Even if the HRT was reduced to 5h, it could still meet the level A Emission Standard. The total methane conversion of AnGMBR was between 0.234 and 0.271L/g COD_R, about 61% to 70% of the influent COD was converted into methane. The particle size and mechanical strength of granular sludge were not different during the operation of AnGMBR, and granular sludge could keep stable. After a period of continuous operation, AnGMBR's TMP kept stable at about 35kPa. The performance of membrane was restored effectively after cleaning. The energy consumption required for the fluidization of granular sludge in AnGMBR was lower, and the permeate water was the main energy consumption required part. The energy output could meet the energy demand. Thus, the AnGMBR system had great potential as an energy positive wastewater treatment system.