4 groups of potential source intensities with 2 pollution sources were obtained using orthogonal experimental design in a landfill of Baicheng city. Numerical simulation models of groundwater flow and solute transport were developed to predict the groundwater contaminated condition resulted by the potential pollution sources, and 57 potential monitoring network were designed according to the distribution of the contamination plume. In order to maximize the coverage of highly polluted areas maximization, a 0-1integer programming model was established which was solved with implicit enumeration method. The result demonstrated that:the optimal groundwater quality monitoring network layout strategies under different maximum allowable monitoring wells number were achieved. Taking the maximum allowable monitoring wells number as 7as an example, then 1, 6, 9, 15, 19, 23, 31 were the optimal location of the monitoring wells (five wells located at downstream of the leachate tank, two wells located at downstream of the landfill area). It was found that the pollutants detection probability with the optimal monitoring network layout strategy reached 95%, which was much higher than that of random layout strategy.