双酚F和双酚S联合暴露下的斑马鱼富集及神经毒性

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Abstract

In orderto investigate the enrichment of bisphenol F (BPF) and bisphenol S (BPS) in zebrafish and their combined neurotoxicity, single and combined exposure of 1, 10, 100, 1000μg/L BPF and BPS was conducted for 14days. The enrichment level of BPF and BPS in zebrafish tissues was positively correlated with the exposure concentration and time, and the enrichment capacity of BPF was higher than that of BPS. Combined exposure of BPF and BPS reduced the enrichment level of BPS in zebrafish, but had little effects on the enrichment of BPF. Toxicity studies on brain tissues showed that BPF induced levels of oxidative damage and inflammation indicators such as malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), interleukin-1β(1L-1β) and tumor necrosis factor α (TNF-α), were higher than those of BPS. Moreover, combined exposure was found to have toxicity enhancement effects. However, the toxic effects of BPS on neurotoxic markers, such as cortisol (COR), epinephrine (EPI) and acetylcholinesterase (AChE), and genes related to neurological functions, such as Syn2a, MBP, Gfap, MAP2, NSE2 and S-100B, were higher than those of BPF. And, combined exposure reduced the effects on AChE, COR and EPI.

Key words： BPF BPS neurotoxicity zebrafish combined exposure

Received: 16 July 2019

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X174

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	Articles by authors
	WANG Qian-qian
	WANG Yong-hua
	WANG Bei-bei
	LIU Xiao-dan
	WU Bing
	LU Guang-hua

Cite this article:

WANG Qian-qian,WANG Yong-hua,WANG Bei-bei等. ccumulation and neurotoxicity of bisphenol F and bisphenol S in zebrafish under combined exposure[J]. CHINA ENVIRONMENTAL SCIENCECE, 2020, 40(2): 865-873.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2020/V40/I2/865

[1]	Huang Y Q, Wong C K C, Zheng J S, et al. Bisphenol A (BPA) in China:A review of sources, environmental levels, and potential human health impacts[J]. Environment International, 2012,42(1):91-99.
[2]	胥志祥,刘君,罗闹,等.DBP和BPA对MCF-7细胞的联合效应及机制[J]. 中国环境科学, 2017,37(12):4771-4780. Xu Z X, Liu J, Luo N, et al. Combined effect of DBP and BPA on MCF-7cells and its mechanism[J]. China Environmental Science, 2017,37(12):4771-4780.
[3]	Niu Y, Wang B, Zhao Y, et al.A highly sensitive and high-throughput method for the analysis of bisphenol analogues and their halogenated derivatives in breast milk[J]. Journal of agricultural and food chemistry, 2017,65(48):10452-10463.
[4]	Fol V L, Selim A A, Sonavane M, et al. In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays[J]. Ecotoxicology and Environmental Safety, 2017,142:150-156.
[5]	Yang F, Qiu W H, Li R Z, et al. Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish[J]. Chemosphere, 2018,213:559-567.
[6]	沈杰,刘建超,陆光华,等.双酚S和双酚F在水环境中的分布、毒理效应及其生态风险研究进展[J]. 生态毒理学报, 2018,13(5):37-48. Shen J, Liu J C, Lu G H et al. Distribution, toxicological effects and ecological risks of bisphenol S and bisphenol F in water environment[J]. Journal of Ecotoxicology, 2018,13(5):37-48.
[7]	Ruth R J, Louise B A.Bisphenol S and F:A systematic review and comparison of the hormonal activity of bisphenol A substitutes[J]. Environmental Health Perspectives, 2015,123(7):643-650.
[8]	王蔚,王子豪,张晓娜.双酚A及其类似物对哺乳动物和鱼类神经毒性效应及机制研究进展[J]. 中国海洋大学学报(自然科学版), 2019,49(5):27-34. Wang W, Wang Z H, Zhang X N. Neurotoxic effects and mechanism of bisphenol A and its analogs on mammals and fish[J]. Journal of Ocean University of China (natural science edition), 2019,49(5):27-34.
[9]	Beatriz C, Pilar S, Torres J M, et al. Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine-serotonin systems in the prefrontal cortex of juvenile female rats[J]. Environmental Research, 2015,142:281-287.
[10]	Raja R, Anne A, Bessem M, et al. Effects of bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin/APJ system in mice[J]. Ecotoxicology and Environmental Safety, 2018,161:459-466.
[11]	Wei P H, Zhao F, Zhang X N, et al. Transgenerational thyroid endocrine disruption induced by bisphenol S affects the early development of zebrafish offspring[J]. Environmental Pollution, 2018,243:800-808.
[12]	孙媛媛,于红霞,沈骅,等.2-硝基-4'-羟基二苯胺(HC Orange No.1)在鲫鱼肝脏中的富集及其对肝脏抗氧化指标的影响[J]. 农业环境科学学报, 2005,24(1):26-30. Sun Y Y, Yu H X, Shen H, et al. Enrichment of 2-nitro-4'-hydroxyl diphenylamine (HC Orange No.1) in crucian carp liver and its effect on its antioxidant index[J]. Journal of Agricultural Environmental Sciences, 2005,24(1):26-30.
[13]	杨方星,丁锦建,黄薇,等.有机磷阻燃剂在室内悬浮颗粒物上的分布特征及其人体暴露评估[C]//第七届全国环境化学大会摘要集.北京:北京出版社, 2013:94-95. Yang F X, Ding J J, Huang W, et al. Distribution characteristics and human exposure assessment of organophosphorus flame retardants in indoor suspended particulate matter[C]//Proceedings of the 7th national conference on environmental chemistry. Beijing:Beijing press, 2013:94-95.
[14]	杨光义,张晨宁,张荣娇,等.具有肝肠循环特征药物诱发的毒副作用及其机制研究进展[J]. 医药导报, 2017,36(3):299-302. Yang G Y, Zhang C N, Zhang R J, et al. Research progress on drug-induced side effects and mechanism with characteristics of liver and intestinal circulation[J]. Chinese journal of medicine, 2017, 36(3):299-302.
[15]	Liu J, Wang R, Huang B, et al.Distribution and bioaccumulation of steroidal and phenolic endocrine disrupting chemicals in wild fish species from Dianchi Lake, China[J]. Environmental Pollution, 2011, 159(10):2815-2822.
[16]	Wu M, Pan C, Yang M, et al. Chemical analysis of fish bile extracts for monitoring endocrine disrupting chemical exposure in water:Bisphenol A, alkylphenols and norethindrone[J]. Environmental Toxicology & Chemistry, 2016,35(1):182-190.
[17]	Wang Q, Chen M, Shan G, et al. Bioaccumulation and bioma-gnification of emerging bisphenol analogues in aquatic organisms from Taihu Lake, China[J]. Science of the Total Environment, 2017, 598:814-820.
[18]	Macczak A, Cyrkler M, Bukowska B, et al. Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study)[J]. Toxicology in Vitro, 2017,41:143-149.
[19]	Nicolas C, Coralie D, Isabelle S, et al. Genotoxic and endocrine act-ivities of bis (hydroxyphenyl) methane (bisphenol F) and its derivatives in the HepG2cell line[J]. Toxicology, 2009,255(1):15-24.
[20]	雷鹏辉.环境内分泌干扰物双酚S和双酚F对斑马鱼早期发育的免疫毒性效应及致毒机理[D]. 上海:上海大学, 2018. Lei P H. Immunotoxic effects of environmental endocrine disruptors bisphenol S and bisphenol F on early development of zebrafish and its toxigenic mechanism[D]. Shanghai:Shanghai University, 2018.
[21]	Jin Y, Chen R, Liu W, et al. Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio)[J]. Fish and Shellfish Immunology, 2010,28(5):854-861.
[22]	卢崇伟.环境内分泌干扰物三氯生、双酚A对斑马鱼的毒性研究[D]. 镇江:江苏大学, 2016. Lu C W. Toxicity of environmental endocrine disruptors triclosan and bisphenol A to zebrafish[D]. Zhenjiang:jiangsu University, 2016.
[23]	胡晓华.生理剂量的双酚A对雄性成年大鼠及其子代空间记忆的影响[C]//中国医学会会议论文集.北京.北京出版社, 2013,63-64. Hu X H. Effects of physiological dose of bisphenol A on spatial memory of male adult rats and their offspring[C]//Proceedings of Chinese medical association conference. Beijing. Beijing press, 2013:63-64.
[24]	郭婧颖,刘建超,李帅衡,等.双酚AF对大型溞生殖、生长等生态行为的影响[J]. 中国环境科学, 2019,39(10):4394-4400. Guo J Y, Liu J C, Li S H, et al. Effects of bisphenol AF on the reproductive growth and other ecological behaviors of daphnia magna[J]. China Environmental science, 2019,39(10):4394-4400.
[25]	Chen D, Kannan K, Tan H, et al. Bisphenol analogues other than BPA:environmental occurrence, human exposure, and toxicity-A review[J]. Environmental Science & Technology, 2016,50(11):5438-5453.
[26]	Qiu W, Shao H, Lei P, et al. Immunotoxicity of bisphenol S and F are similar to that of bisphenol A during zebrafish early development[J]. Chemosphere, 2018,194:1-8.
[27]	Zhou X, Kramer J P, Calafat A M, et al. Automated on-line column-switching high performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of bisphenol A, bisphenol F, bisphenol S, and 11other phenols in urine[J]. Journal of Chromatography B, 2014,944:152-156.
[28]	贺诗静.诺氟沙星对斑马鱼胚胎的神经毒性及机制研究[D]. 武汉:武汉大学, 2017. He S J. Neurotoxicity and mechanism of norfloxacin on zebrafish embryos[D]. Wuhan:Wuhan University, 2017.
[29]	王飞,徐凌,姜婷婷.神经元特异性烯醇化酶在不同病因所致脑损伤中的鉴别诊断价值[J]. 医学研究杂志, 2016,45(11):141-144. Wang F, Xu L, Jiang T T. Differential diagnosis value of neuron-specific enolase in brain injury caused by different etiology[J]. Journal of Medical Research, 2016,45(11):141-144.
[30]	Iwakura T, Iwafuchi M, Muraoka D, et al. In vitro effects of bisphenol A on developing hypothalamic neurons[J]. Toxicology, 2010,272(1):52-58.