可吸入颗粒物在不同阻塞性呼吸道内运动与沉积特性

Abstract
Figure/Table
References
Related Citation (1)

Download: PDF (1976 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract In order to figure out the movement and deposition of particles in the respiratory tract of workers with chronic obstructive pulmonary disease, the numerical simulations were performed to study the gas-solid flow characteristics in two types of obstructive airways. Also, the effects of the following parameters, such as obstructive rate (α), lesion location and labor intensity on flow field, particle deposition pattern and deposition efficiency were analyzed. Results indicated that the greater alpha was, the more severe the local anoxia was. When α = 0.8, the relative oxygen deficit was larger than 90%, and the stronger the labor intensity or the deeper the blocking position, the higher the possibility of asthma. Respiratory tract deformation did not change the deposition mechanism of particles, but but had a significant effect on its deposition pattern. The asymmetry of particle deposition distribution enhanced with the increasing α, the labor intensity and particle size, of which was better in lower respiratory tract. Moreover, the respiratory tract deformation reduced the total sedimentation rate (η_t), and the larger α, the smaller η_t. It was also found that α had a more significant effect on η_t for lower labor intensity, lower respiratory tract or particle diameter larger than 5μm.

Key words： chronic obstructive pulmonary disease (COPD) obstructive degree lesion location gas-solid two phase flow deposition characteristics of particles

Received: 22 November 2020

PACS:

X513

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHUANG Jia-wei
	DIAO Yong-fa
	CHU Ming-hao
	SHEN Heng-gen

Cite this article:

ZHUANG Jia-wei,DIAO Yong-fa,CHU Ming-hao等. Transport and deposition characteristics of inhalable particulate matters in different obstructive airways[J]. CHINA ENVIRONMENTAL SCIENCECE, 2021, 41(7): 3349-3359.

URL:

http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2021/V41/I7/3349

[1]	Baur X, Sanyal S, Abraham J L. Mixed-dust pneumoconiosis:Review of diagnostic and classification problems with presentation of a work-related case[J]. Science of the Total Environment, 2019,652:413-421.
[2]	Mandrioli D, Schlünssen V, Adam B, et al. WHO/ILO work-related burden of disease and injury:Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis[J]. Environment International, 2018,119:174-185.
[3]	Muneswarao J, Verma A K, Hassali M A A. Global initiative for chronic obstructive lung disease (GOLD) 2018 report:Highlighting an incorrect information[J]. Pulmonary Pharmacology and Therapeutics, 2018,49:10.
[4]	Turner M C, Krewski D, Pope III C A, et al. Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers[J]. American Journal of Respiratory and Critical Care Medicine, 2011,184(12):1374-1381.
[5]	张姝琳,张漫雯,冯桂贤,等.汽车铸造厂车间PCDD/Fs污染及车间工人呼吸暴露评估[J]. 中国环境科学, 2015,35(12):3779-3785. Zhang S L, Zhang M W, Feng G X, et al. Air pollution and occupational inhalation exposure of PCDD/Fs in an automobile foundry[J]. China Environmental Science, 2015,35(12):3779-3785.
[6]	Grgic B, Martin A R, Finlay W H. The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses[J]. Journal of Aerosol Science, 2006,37(10):1222-1233.
[7]	Kim C S, Fisher D M. Deposition characteristics of aerosol particles in sequentially bifurcating airway models[J]. Aerosol Science and Technology, 1999,31(2/3):198-220.
[8]	Zhou Y, Cheng Y S. Particle deposition in a cast of human tracheobronchial airways[J]. Aerosol Science and Technology, 2005, 39(6):492-500.
[9]	李福生,徐新喜,孙栋,等.气溶胶颗粒在人体上呼吸道模型内沉积的实验研究[J]. 医用生物力学, 2013,(2):135-141. Li F S, Xu X X, Sun D, et al. Experimental study on the deposition of aerosol particles in human upper respiratory tract model[J]. Journal of Medical Biomechanics, 2013,(2):135-141.
[10]	Phuong N L, Ito K. Investigation of flow pattern in upper human airway including oral and nasal inhalation by PIV and CFD[J]. Building and Environment, 2015,94:504-515.
[11]	Comer J K, Kleinstreuer C, Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields[J]. Journal of Fluid Mechanics, 2001,435:25-54.
[12]	Comer J K, Kleinstreuer C, Kim C S. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition[J]. Journal of Fluid Mechanics, 2001,435:55-80.
[13]	Kleinstreuer C, Zhang Z, Kim C S. Combined inertial and gravitational deposition of microparticles in small model airways of a human respiratory system[J]. Journal of Aerosol Science, 2007, 38(10):1047-1061.
[14]	Nicolaou L. Inertial and gravitational effects on aerosol deposition in the conducting airways[J]. Journal of Aerosol Science, 2018,120:32-51.
[15]	Tian L, Ahmadi G. Transport and deposition of nano-fibers in human upper tracheobronchial airways[J]. Journal of Aerosol Science, 2016, 91:22-32.
[16]	Feng Y, Kleinstreuer C, Rostami A. Evaporation and condensation of multicomponent electronic cigarette droplets and conventional cigarette smoke particles in an idealized G3-G6 triple bifurcating unit[J]. Journal of Aerosol Science, 2015,80:58-74.
[17]	Jia L, Zhang L, Yu S. Deposition of non-spherical microparticles in the human upper respiratory tract[J]. Particuology, 2018,36:185-189.
[18]	Kiasadegh M, Emdad H, Ahmadi G, et al. Transient numerical simulation of airflow and fibrous particles in a human upper airway model[J]. Journal of Aerosol Science, 2020,140:105480.
[19]	Huang J, Zhang L. Numerical simulation of micro-particle deposition in a realistic human upper respiratory tract model during transient breathing cycle[J]. Particuology, 2011,9(4):424-431.
[20]	Chen X, Kleinstreuer C, Zhong W, et al. Effects of thermal airflow and mucus-layer interaction on hygroscopic droplet deposition in a simple mouth-throat model[J]. Aerosol Science and Technology, 2018,52(8):900-912.
[21]	Tohidi R, Sajadi B, Ahmadi G. The effect of nasal airway obstruction on the dispersion and deposition of inhaled volatile droplets in the human nasal cavity:A numerical study[J]. Journal of Aerosol Science, 2020,150:105650.
[22]	Chen W H, Lee K H, Mutuku J K, et al. Flow dynamics and PM2.5 deposition in healthy and asthmatic airways at different inhalation statuses[J]. Aerosol Air Quality and Research, 2018,18:866-883.
[23]	Chen X, Ma R, Zhong W, et al. Numerical study of the effects of temperature and humidity on the transport and deposition of hygroscopic aerosols in a G3-G6airway[J]. International Journal of Heat and Mass Transfer, 2019,138:545-552.
[24]	Deng Q, Ou C, Shen Y M, et al. Health effects of physical activity as predicted by particle deposition in the human respiratory tract[J]. Science of The Total Environment, 2019,657:819-826.
[25]	Zhang Z, Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model[J]. Physics of Fluids, 2002,14(2):862-880.
[26]	Chen X, Zhong W, Zhou X, et al. CFD-DEM simulation of particle transport and deposition in pulmonary airway[J]. Powder Technology, 2012,228:309-318.
[27]	Feng Y, Kleinstreuer C. Micron-particle transport, interactions and deposition in triple lung-airway bifurcations using a novel modeling approach[J]. Journal of Aerosol Science, 2014,71:1-15.
[28]	Luo H Y, Liu Y, Yang X L. Particle deposition in obstructed airways[J]. Journal of Biomechanics, 2007,40(14):3096-3104.
[29]	Chen X, Zhong W, Sun B, et al. Study on gas/solid flow in an obstructed pulmonary airway with transient flow based on CFD-DPM approach[J]. Powder Technology, 2012,217:252-260.
[30]	Zhang W, Xiang Y, Lu C, et al. Numerical modeling of particle deposition in the conducting airways of asthmatic children[J]. Medical Engineering and Physics, 2020,76:40-46.
[31]	Rizzo D C. Fundamentals of anatomy and physiology[Z]. Cengage Learning, 2015:409-430.
[32]	Hegedűs C J, Balásházy I, Farkas A. Detailed mathematical description of the geometry of airway bifurcations[J]. Respiratory Physiology & Neurobiology, 2004,141(1):99-114.
[33]	Zhang Z, Kleinstreuer C, Kim C S. Flow structure and particle transport in a triple bifurcation airway model[J]. Journal of Fluids Engineering, 2001,123(2):320-330.
[34]	Kim C S, Fisher D M. Deposition characteristics of aerosol particles in sequentially bifurcating airway models[J]. Aerosol Science & Technology, 1999,31(2/3):198-220.
[35]	Deng Q, Ou C, Shen Y M, et al. Health effects of physical activity as predicted by particle deposition in the human respiratory tract[J]. Science of the Total Environment, 2019,657:819-826.