栉孔扇贝对8:2FTCA的代谢转化与氧化应激响应

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Abstract The metabolic transformation characteristics and oxidative stress response of Chlamys farreri to 8:2 fluorotelomeric acid (8:2 FTCA) were studied. Five metabolites of 8:2 FTCA were identified in C.farreri, inclubng 8:2 fluorotelomer unsaturated carboxylic acid (8:2 FTUCA), 7:3 fluorotelomer carboxylic acid (7:3 FTCA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluoroheptanoic acid (PFHpA). Gill and liver were the main metabolic target organs which the total concentration of metabolites were the highest. The biotransformation characteristics of 8:2 FTCA in C.farreri was similar with that in Patinopecten yessoensis, such as the detected metabolites, the metabolic target organs, and the main tissue for the accumulation and metabolism of PFOA (gill). The difference was the main metabolite of C.farreri is 7:3 FTCA while P.yessoensis is PFOA. The key antioxidant enzymes in gill and liver were activated significantly. Oxidative stress indicators such as malondialdehyde (MDA) and glutathione (GSH), antioxidant enzymes such as glutathione peroxidase (GSH-Px),superoxide dismutase (SOD) and catalase (CAT) changed in different degrees:GSH-Px was inhibited continuously during the entire experiment, SOD and CAT activities were induced in gill, and showed obvious dose-effect relationships in the liver:inhibited in the low-dose treated groups, and induced in high-dose treated groups. The content of GSH and MDA showed a dose-response relationship as well as tissue variability. In addition, physiological indicators recovered in various degrees at the end of the exposure experiment.

Key words： fluorotelomer carboxylic acids (FTCAs) perfluocarboxylic acids (PFCAs) biotransformation antioxidant enzymes Chlamys farreri

Received: 17 March 2021

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X171.5

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	Articles by authors
	LIU Xiao-yu
	GUO Jiao
	WANG Zhi
	TAN Zhi-jun
	ZHAI Yu-xiu
	GUO Meng-meng

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LIU Xiao-yu,GUO Jiao,WANG Zhi等. Metabolic transformation and physiological response of Chlamys farreri to 8:2 fluorotelomer carboxylic acid (8:2FTCA)[J]. CHINA ENVIRONMENTAL SCIENCECE, 2021, 41(10): 4904-4915.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2021/V41/I10/4904

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