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| Alleviating cadmium toxicity to liver and kidney of mice with dietary supplementation of selenium and calcium in combination |
| WU Yang-yang1, PENG Xiang-wen1, SHI Ke-xin1, KUANG Wen-jie1, SUN Hong2, HUANG Lei1 |
1. State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China;
2. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210023, China |
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Abstract To explore the mitigation role of dietary selenium (Se) and calcium (Ca) supplementation in combination in alleviating the biological toxicity of Cd, an in vivo mouse bioassay was performed. Mice (BALB/c, n = 88) that were exposed to Cd via diets at the same concentration of 2mg/kg were randomly divided to 19groups of dietary supplementation of low, medium, and high concentrations of Se and Ca in diets alone or in combination. The growth and development of mice, liver and kidney function, oxidative stress state and histopathological changes of the mice were measured after 30days of intervention. Results showed that the combined intervention of Se-Ca could effectively alleviate the growth retardation of mice caused by Cd exposure. In terms of liver and kidney function and oxidative stress, the combined intervention had a stronger protective effect on AST, GSH, SOD, GSH-Px in the liver and BUN, MDA and SOD in the kidney of mice than single Se or Ca intervention. Additionally, a lower dietary concentration of Se and Ca in combination alleviated pathological damage at a similar extent to that of a high concentration of Se or Ca alone. In general, Se-Ca dietary intervention in combination effectively alleviated the growth retardation and liver and kidney toxicity of mice caused by Cd exposure, and the effect was stronger than that of single element intervention.
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Received: 06 August 2021
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