聚苯乙烯微塑料对糖尿病小鼠肾脏的影响

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Abstract Diabetic mice were used as model organisms to investigate the toxicity of 100nm and 5μm polystyrene microplastics (PSMPs) (200μg/L) after exposure to drinking water for 28days. The results of the study indicated that diabetic mice were more sensitive to the exposure of PSMPs. Exposure to 100nm and 5μm PSMPs led to obvious pathological damage such as inflammatory cell infiltration and congestion in the kidneys of diabetic mice, and 100nm PSMP caused more severe pathological damage to the kidney. In addition, exposure to 100nm PSMPs significantly aggravated the expression levels of renal inflammatory factors (TNF-α and IL-6), superoxide dismutase (SOD) and serum creatinine in diabetic mice, and caused renal metabolic disorders. Compared with 5μm PSMPs, the small particle size toxicity exhibited by microplastics may be related to the easier accumulation of nano-level PSMPs in the kidneys through the intestinal barrier. Moreover, the impaired glycolysis and reduced energy metabolism levels caused by disorders of renal metabolic pathways also increased the burden of PSMPs on kidneys of diabetic mice.

Key words： polystyrene microplastics diabetic mice kidney inflammation oxidative stress

Received: 18 August 2021

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X174

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	LI Huan
	LIU Su
	ZHANG Jing-li
	CHEN Jian-qiu

Cite this article:

LI Huan,LIU Su,ZHANG Jing-li等. Effects of polystyrene microplastics on kidney of diabetic mice[J]. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(3): 1369-1378.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2022/V42/I3/1369

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