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| Recent advances on antibiotic resistance genes encoded by bacteriophages |
| ZHANG Yue1, HU Xue-ying1,2, WANG Xu-ming1 |
1. Institute of Biotechnology, Beijing Academy of Agriculture and Forestry Sciences, Beijing Key Laboratory of Agricultural Genetic Resources and Biotechnology, Beijing 100097, China;
2. College of Forestry, Northeast Forestry University, Harbin 100040, China |
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Abstract Bacteriophages (phages), the most abundant biological entities on earth, have a great effect on the composition and diversity of microbial community, biogeochemical cycle of global ecosystem and bacterial evolution. However, the contribution of bacteriophages to antibiotic resistome is still poorly understood. Several researches found that there were a variety of antibiotic resistance genes (ARGs) in phage genomes at different environmental sites such as ocean, river, soil and faeces by metagenomics sequencing and quantitative PCR technology. Therefore, bacteriophage and phages-mediated transduction may play an important role in the enrichment and spread of ARGs. Here, the distribution characteristics of ARGs in phage genomes at different environmental settings and the research progress of horizontal transfer of ARGs mediated by phage were reviewed. Meanwhile, the unsolved scientific problems were put forward. This article would lay a foundation for understanding the role of phages in the spread of ARGs and expanding the knowledge about mobile resistome.
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Received: 30 September 2021
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