溴氰菊酯对稀有鮈鲫早期生命阶段发育和内分泌干扰毒性

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Abstract The developmental toxicity and endocrine disrupting effects of decamethrin on rare minnow (Gobiocypris rarus) during early life stage were studied using semi-static water exposure method. The LOEC (lowest observed effect concentration) of decamethrin to the incubation of rare minnow embryo was above 3.0μg/L. The LOEC and NOEC (no observed effect concentration) of decamethrin to the developmental malformations and death indicators were 1.0 and 0.33μg/L, respectively. Exposure to the lowest concentration of decamethrin (0.04μg/L) could significantly down-regulate the expression of androgen receptor gene (AR) and up-regulate the expression of thyroid homone receptor gene (TRβ) in rare minnow larvae. Exposure to 0.11μg/L decamethrin down-regulated the expressions of AR, estrogen receptor genes (ER1, ER2b) and aromatic hydrocarbon receptor gene (AhR1a) in rare minnow larvae, and up-regulated the expressions of TRβ. Exposure to 0.33μg/Ldecamethrin inhibited the expressions of AR, estrogen receptor genes (ER1, ER2b) and aromatic hydrocarbon receptor genes (AhR1a, AhR1b, AhR2), as well as induced the expression of TRβ in rare minnow larvae. Given that these concentration levels have been in the range of detectable decamethrin concentrations in multiple natural water bodies, more attention should be paid to the endocrine disrupting effects of decamethrin on fish.

Key words： decamethrin rare minnow early life stage developmental toxicity endocrine disruption

Received: 18 October 2021

PACS:	X171
	Q89

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	Articles by authors
	JIANG Jin-lin
	LYU Jian-wei
	CAO Shao-hua
	LIU Ren-bin
	SHI Jia-qi
	LONG Tao
	SHAN Zheng-jun

Cite this article:

JIANG Jin-lin,LYU Jian-wei,CAO Shao-hua等. Developmental toxicity and endocrine disrupting effects of deltamethrin on rare minnow (Gobiocypris rarus) during early life stage[J]. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(5): 2395-2403.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2022/V42/I5/2395

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