大气污染暴露与育龄妇女月经周期长度的关联

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Abstract 343reproductive aged women permanently dwelling in Shanxi were recruited to conduct a cross-sectional study for the association between ambient air pollution exposure and menstrual cycle length. Based on physiological characteristics of menstrual cycle length, exposure windows for menstrual cycle length were designed. Daily concentrations of sulfur dioxide (SO₂), nitrogen dioxide (NO₂), particulate matters with the diameter≤2.5µm (PM_2.5), and ozone (O₃) were obtained from local air quality monitoring stations. Generalized linear model (GLM) was employed to evaluate the association of ambient air pollution exposure with total menstrual cycle length, follicular phase length, and luteal phase length during distinct exposure windows. SO₂ exposure level in Q4 group were significantly associated with prolonged total menstrual cycle length during period 1(0.053; 95%CI: 0.022, 0.083), period 2(0.049; 95%CI: 0.02, 0.078), and period 3(0.045; 95%CI: 0.017, 0.073). Furthermore, the effect of SO₂ exposure was particularly on the prolongation of follicular phase. Similarly, NO₂ exposure level in Q3 group were significantly associated with prolonged total menstrual cycle length during period 1(0.060; 95CI: 0.035, 0.085), period 2(0.056; 95CI: 0.030, 0.083), and period 3(0.050; 95CI: 0.025, 0.075). PM_2.5 exposure level in Q3 group were significantly associated with prolonged total menstrual cycle length during period 1(0.043; 95%CI: 0.012, 0.074) and period 2(0.049; 95%CI: 0.020, 0.079). However, O₃ exposure level in Q4group were significantly associated with shortened follicular phase during period 1(-0.043; 95% CI: -0.079, -0.003), period 2(-0.047; 95%CI: -0.072, -0.022), and period 3(-0.046; 95CI: -0.081, -0.011). In summary, follicular phase of menstrual cycle may be sensitive to ambient air pollution exposure. Moreover, the significant association of ambient air pollution exposure and menstrual cycle length was still observed even when exposed below Chinese existing standard levels. Our findings provided important reference evidence of precise formulation of atmospheric pollution control measures in China and accelerate implementation of regional health risk prevention policy.

Key words： atmospheric pollution menstrual cycle length female fertility health risk pollution prevention

Received: 31 May 2022

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	FENG Xiao-qin
	LUO Jin-hong
	XIE Wo-long
	WANG Na
	QIN Guo-hua

Cite this article:

FENG Xiao-qin,LUO Jin-hong,XIE Wo-long等. Association of atmospheric pollution exposure with menstrual cycle length among fertile women[J]. CHINA ENVIRONMENTAL SCIENCECE, 2023, 43(1): 374-382.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2023/V43/I1/374

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