|
|
|
| Antibiotic pollution characteristics and risk assessment of surface water in Yongding River Mentougou District |
| JIANG Bao, LING Wen-cui, WANG Ya-ling, JING Xiang-long, YANG Yong, SUN Cheng-yi |
| National Engineering Research Center for Urban Environmental Pollution Control, Beijing Municipal Research Institute of Eco-Environmental Protection, Beijing 100037, China |
|
|
|
|
Abstract Antibiotic pollution characteristics and risks in Mentougou District section of Yongding River (including the downstream of Guanting Reservoir, the main stream after the tributaries of Zaitang Reservoir converge, and the urban section) were evaluated by high performance liquid chromatography-tandem triple quadrupole mass spectrometry. The results showed that florfenicol, olsalazine, and sulfamethoxazole were detected in all three sections, with average concentrations of 4.95ng/L, 2.56ng/L, and 13.96ng/L, respectively. Sulfapyridine was introduced from tributaries with a detection rate of 54%, and the concentration increased from 2.36ng/L to 4.06ng/L. The content of ofloxacin increased significantly in the urban section due to the impact of domestic sewage discharge, reaching a concentration of 7.93ng/L. Overall, there was no health risk in the Mentougou District section of Yongding River. However, after entering the urban section, the ecological and resistance risks increased, which may be due to the increase of human activity levels and requires further attention.
|
|
Received: 07 October 2023
|
|
|
|
|
|
[1] Pan C, Bao Y, Xu B. Seasonal variation of antibiotics in surface water of Pudong New Area of Shanghai, China and the occurrence in typical wastewater sources[J]. Chemosphere, 2020,239:124816.
[2] Qiu W, Sun J, Fang M, et al. Occurrence of antibiotics in the main rivers of Shenzhen, China:Association with antibiotic resistance genes and microbial community[J]. Science of The Total Environment, 2019, 653:334-341.
[3] Liu X, Lu S, Meng W, et al. Occurrence, source, and ecological risk of antibiotics in Dongting Lake, China[J]. Environmental Science and Pollution Research, 2018,25(11):11063-11073.
[4] Hanna N, Sun P, Sun Q, et al. Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China:Its potential for resistance development and ecological and human risk[J]. Environment International, 2018,114:131-142.
[5] Li S, Liu Y, Wu Y, et al. Antibiotics in global rivers[J]. National Science Open, 2022,1(2):20220029.
[6] Zainab S M, Junaid M, Xu N, et al. Antibiotics and antibiotic resistant genes (ARGs) in groundwater:A global review on dissemination, sources, interactions, environmental and human health risks[J]. Water Research, 2020,187:116455.
[7] Östman M, Lindberg R H, Fick J, et al. Screening of biocides, metals and antibiotics in Swedish sewage sludge and wastewater[J]. Water Research, 2017,115:318-328.
[8] Zhang Q, Cheng J, Xin Q. Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos[J]. Ecotoxicology, 2015,24(4):707-719.
[9] Qiu W, Hu J, Magnuson J T, et al. Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway[J]. Environmental International, 2020,138:105624.
[10] Brain R A, Hanson M L, Solomon K R, et al. Aquatic plants exposed to pharmaceuticals:effects and risks[J]. Reviews of Environmental Contamination and Toxicology, 2008,192:67-115.
[11] Grenni P, Ancona V, Barra Caracciolo. A Ecological effects of antibiotics on natural ecosystems:A review[J]. Microchemical Journal, 2018,136:25-39.
[12] Wang H, Wang N, Wang B, et al. Antibiotics in drinking water in shanghai and their contribution to antibiotic exposure of school children[J]. Environmental Science and Technology, 2016,50(5):2692-2699.
[13] Liu Y J, Wang S Q, Pan J L, et al. Antibiotics in urine of the general population:Exposure, health risk assessment, and food factors[J]. Journal of Environmental Science and Health, Part B, Pesticides, Food Contaminants, and Agricultural Wastes, 2022,57(1):1-12.
[14] Liu X J, Zhang J J, Sang Y R, et al. Antibiotic exposure and potential risk of depression in the Chinese elderly:a biomonitoring-based population study[J]. Environmental Science and Pollution Research, 2021,28(21):26794-26806.
[15] 李振环,朱英,胡小键,等.抗生素的人体健康风险、内暴露特征及检测技术研究进展[J].环境化学, 2023,42(12):1-16. Li Z H, Zhu Y, Hu X J, et al. Research progress on human health risk, internal exposure characteristics and analysis technologies of antibiotics[J]. Environmental Chemistry, 2023,42(12):1-16.
[16] 黄福义,周曙仡聃,王佳妮,等.不同作物农田土壤抗生素抗性基因多样性[J].环境科学, 2021,42(6):2975-2980. Huang F Y, Zhou S Y D, Wang J N, et al. Profiling of antibiotic resistance genes in different croplands[J]. Environmental Science, 2021,42(6):2975-2980.
[17] 张盼伟.海河流域典型水体中PPCPs的环境行为及潜在风险研究[D].北京:中国水利水电科学研究院, 2018. Zhang P W. Enviromental behavior and pollution characteristics of pharmaceuticals and personal care products, and their associated environmental risks in typical water-body from Haihe river basin, China[D]. Beijing:China Institute of Water Resources and Hydropower Research, 2018.
[18] Papageorgiou M, Zioris I, Danis T, et al. Comprehensive investigation of a wide range of pharmaceuticals and personal care products in urban and hospital wastewaters in Greece[J]. Science of The Total Environment, 2019,694:133565.
[19] 环境保护部.中国人群暴露参数手册,成人卷[M].北京:中国环境出版社, 2013. Ministry of Ecology and Environment of the Peoples's Republic of China. Highlights of the Chinese exposure factors handbook (Adults)[M]. Beijing:China Environmental Press, 2013.
[20] Bengtsson-Palme J, Larsson D G Concentrations of antibiotics predicted to select for resistant bacteria:Proposed limits for environmental regulation[J]. Environmental International, 2016,86:140-149.
[21] 李红婵,段凯,汪聪勇,等.氟苯尼考药动学及残留检测研究进展[J].安徽农业科学, 2022,50(21):9-12. Li G C, Duan K, Wang C Y, et al. Research progress in pharmacokinetics and residue detection of florfenicol[J]. Journal of Anhui Agricultural Sciences, 2022,50(21):9-12.
[22] 戴佳佳,宋金明,李学刚,等.中国典型水域磺胺类合成药物的环境生物地球化学特征[J].海洋与湖沼, 2023,54(4):935-950. Dai J J, Song J M, Wang Q Y, et al. Environmental biogeochemical characteristics of sulfornamides in typical quuatic environments of China[J]. Journal of Oceanologia and Limnologia, 2023,54(4):935-950.
[23] Chen H, Jing L, Teng Y, et al. Characterization of antibiotics in a large-scale river system of China:Occurrence pattern, spatiotemporal distribution and environmental risks[J]. Science of the Total Environment, 2018,618:409-418.
[24] 杨尚乐,王旭明,王伟华,等.松花江哈尔滨段及阿什河抗生素的分布规律与生态风险评估[J].环境科学, 2021,42(1):136-146. Yang S L, Wang X M, Wang W H, et al. Distribution and ecological risk assessment of antibiotics in the Songhua River basin of the Harbin Section and Ashe River[J]. Environmental Science, 2021,42(1):136-146.
[25] 营娇龙,秦晓鹏,郎杭,等.超高效液相色谱-串联质谱法同时测定水体中37种典型抗生素[J].岩矿测试, 2022,41(3):394-403. Ying J L, Qin X P, Lang H, et al. Determination of 37 typical antibiotics by liquid chromatography-triple quadrupole mass spectrometry[J]. Rock and Mineral Analysis, 2022,41(3):394-403.
[26] 赵岳.我国2018年版国家基本药物目录的初步研究[D].郑州:郑州大学, 2019. Zhao Y. Research on the national essential drugs list of China in 2018[D]. Zhengzhou:Zhengzhou University, 2019.
[27] 胡玮,罗阳,胡雯.永定河水系12种抗生素的污染特征分析[J].海河水利, 2019,(4):18-20. Hu W, Luo Y, Hu W. Analysis of pollution characteristics of 12 antibiotics in Yongding River system[J]. Haihe Water Resources, 2019,(4):18-20.
[28] U.S. Food and Drug Administration. Environmental assessment for AQUAFLOR (Florfenicol)50% type a medicated article fed at a dose up to 15mg florfenicol/kg body weight/day for control of mortality associated with bacterial diseases in freshwater-reared finfish in recirculating aquaculture systems[R]. 2013.
[29] Ferrari B, Mons R, Vollat B, et al. Environmental risk assessment of six human pharmaceuticals:are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?[J]. Environmental Toxicology and Chemistry, 2004, 23(5):1344-1354.
[30] Huang F, An Z, Moran M J, et al. Recognition of typical antibiotic residues in environmental media related to groundwater in China (2009~2019)[J]. Journal of Hazardous Materials, 2020,399:122813.
[31] Huang F, Zou S, Deng D, et al. Antibiotics in a typical karst river system in China:Spatiotemporal variation and environmental risks[J]. Science of The Total Environment, 2019,650:1348-1355.
[32] Nunes B. Carvalho FGuilhermino L Acute toxicity of widely used pharmaceuticals in aquatic species:Gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii[J]. Ecotoxicology and Environmental Safety, 2005,61(3):413-419.
[33] Sanderson H, Johnson D J, Wilson C J, et al. Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screening[J]. Toxicology Letters, 2003,144(3):383-395.
[34] Hernando M D, Mezcua M, Fernández-Alba A R, et al. Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments[J]. Talanta, 2006,69(2):334-342.
[35] 陈昱如,段艳平,张智博,等.长江经济带水环境中抗生素人体健康风险评价[J].中国环境科学, 2023,43(7):3713-3729. Chen Y R, Duan Y P, Zhang Z B, et al. Human health risk assessment of antibiotics in the water environment of Yangtze River Economic Belt[J]. China Environmental Science, 2023,43(7):3713-3729. |
|
|
|
