广州市新生儿有机氯农药暴露特征及与激素水平的关联性初探

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Abstract To investigate the impact of organochlorine pesticides (OCPs) exposure during pregnancy on neonatal sex hormone levels and birth physique, this study recruited 271 mother-infant pairs from Guangzhou and collected meconium samples within 24hours postpartum. The levels of ten OCPs and seven sex hormones in meconium were analyzed. The generalized linear model (GLM) was employed to explore the association between OCP exposure and birth physique scores. Additionally, the mediation effect model was utilized to assess the mediating role of sex hormones in the relationship between OCP exposure and birth physique scores. The results indicated that the predominant OCPs in neonatal meconium was p,p'-DDE, with concentration range of not detected (nd) to 0.25nmol/g (median 0.05nmol/g). The median levels of progesterone (P4), androstenedione (AED), testosterone (T), estrone (E1), estradiol (E2), and estriol (E3) in meconium were 1.80, 0.24, 0.13, 0.15, 0.38, and 8.24nmol/g respectively. For each unit increase in p,p'-DDE exposure level, AED, T, and E3 in meconium increased by 1.82 (95% CI: 0.34, 3.29), 1.31 (95% CI: 0.03, 2.60), and 211 (95% CI: 120, 302), respectively. In male newborns, for each unit increase in p,p'-DDE concentration was associated with an increase of 9.12 (95% CI: 3.11, 14.9) in E3leevels. Conversely, in female newborns, for each unit increase in Σ₁₀OCPs concentration resulted in a decrease of 11.8 (95% CI: - 22.8, - 0.84) in the E2/T ratio. Exposure to p,p' - DDE may influence the birth length-Zscore (BLZ) in male neonates through the regulation of E3, with an indirect effect of 0.73 and a mediation effect percentage of 25.3%. Exposure to Σ₁₀OCPs may impact head circumference-Zscore (HCZ) in female neonates via regulating E2/T ratio, with an indirect effect of - 0.18 and a mediation effect percentage of 19.4%. Exposure to OCPs during pregnancy may affect the changes in birth physique scores of neonates by regulating their sex hormone levels.

Key words： organochlorine pesticides prenatal exposure meconium sex hormones birth physical

Received: 14 October 2024

PACS:

X18

Corresponding Authors: 郑晶,责任作者,研究员,zhengjing@scies.org E-mail: zhengjing@scies.org

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	HE Ting
	CAI Feng-shan
	TANG Bin
	YAN Xiao
	LIAO Qi-long
	QIN Rui-xing
	MA Lu
	XIE Chun
	ZHENG Jing

Cite this article:

HE Ting,CAI Feng-shan,TANG Bin等. A preliminary study on the exposure of organochlorine pesticides in neonates and their association with hormone levels in Guangzhou[J]. CHINA ENVIRONMENTAL SCIENCECE, 2025, 45(4): 2264-2275.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2025/V45/I4/2264

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