金属纳米材料对细菌耐药的影响及其机制研究进展

龙琳; 朱琳; 汤惠茗; 汪美贞

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中国环境科学 ›› 2025, Vol. 45 ›› Issue (5) : 2857-2864.

新污染物

金属纳米材料对细菌耐药的影响及其机制研究进展

龙琳¹, 朱琳¹, 汤惠茗^1,2, 汪美贞^1,2

作者信息 +

Research progress on the effect of metallic nanomaterials on the resistance of bacteria and its mechanism

LONG Lin¹, ZHU Lin¹, TANG Hui-ming^1,2, WANG Mei-zhen^1,2

Author information +

文章历史 +

摘要

抗生素耐药性是21世纪人类面临的最严峻的公共健康问题之一.金属纳米材料因其优良的生物杀灭能力和可调节特性,被视为后抗生素时代应对细菌耐药的有效武器.然而,近年来有研究表明,细菌不仅对纳米材料本身可产生抗性,同时这些纳米材料反过来也会影响细菌的生理特性,导致其对抗生素的耐药性增加.综述了金属纳米材料暴露引起的细菌对抗生素耐药性的变化,并从纳米材料与细菌细胞之间的相互作用、细菌基因突变和抗性基因的传播扩散等方面探讨其作用机制.旨在为开发新型纳米抗菌剂提供理论基础,促进纳米材料在抗菌领域的应用,以应对全球耐药性挑战.

Abstract

Antibiotic resistance was recognized as one of the most critical public health challenges confronted by humanity in the 21 st century. Metal nanomaterials were regarded as potent alternatives in the post-antibiotic era, attributed to their exceptional biocidal efficacy and tunable properties. However, it was demonstrated through recent studies that not only could resistance to nanomaterials themselves be developed by bacteria, but the physiological characteristics of bacteria could also be altered, consequently leading to enhanced antibiotic resistance. The antibiotic resistance variations induced by metal nanomaterials were systematically reviewed, with underlying mechanisms being elucidated through three key aspects: the interfacial interactions between nanomaterials and bacterial membranes, the occurrence of bacterial genomic mutations, and the horizontal transfer of resistance genes. This investigation was designed to establish a theoretical framework for innovating next-generation nano-antimicrobial agents, while simultaneously promoting the application of nanomaterials in combating antimicrobial resistance on a global scale.

导出引用

龙琳, 朱琳, 汤惠茗, 汪美贞. 金属纳米材料对细菌耐药的影响及其机制研究进展[J]. 中国环境科学. 2025, 45(5): 2857-2864

LONG Lin, ZHU Lin, TANG Hui-ming, WANG Mei-zhen. Research progress on the effect of metallic nanomaterials on the resistance of bacteria and its mechanism[J]. China Environmental Science. 2025, 45(5): 2857-2864

中图分类号： X172

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