Abstract：The association between skin lesions and DNA oxidative damage among a chronic arsenic exposure population was studied by investigating 199 cases with skin lesions and 91 without skin lesions (control group). Concentrations of inorganic arsenic (iAs) in urinary, monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and 8-hydroxydeoxyguanine (8-OHdG) were measured. Multiple logistic regression was performed to discover the association between skin lesions and DNA oxidative damage. Among participants with skin lesions and without skin lesions, median (interquartile range) of 8-OHdG concentrations in urine were 4.9μg/g creatinine (3.5~6.3) and 5.3(4.1~7.2)μg/g creatinine, respectively. There was no significant difference in 8-OHdG concentrations between case and control group (P=0.074). After adjusting for potential confounding factors, such as age, body mass index (BMI), cigarette smoking, alcohol consumption, and the number of years to high arsenic contaminated water, the results of multiple logistic regression showed that the odds ratio (95% confidence interval, 95% CI) of 8-OHdG in cases with skin lesions was 1.1(0.6,1.9) compared with participants without skin lesions. Skin lesions did not cause significantly increase of 8-OHdG concentrations (P=0.863). There was no significant association between skin lesions and DNA oxidative damage in an arsenic exposure population in Inner Mongolia.
毛广运, 杨佐鹏, 任春生, 叶晓蕾, 王怡, 郭小娟. 环境砷中毒人群皮肤损害与DNA氧化损伤的关联性[J]. 中国环境科学, 2010, 30(1): 99-103.
MAO Guang-Yun, YANG Zuo-Peng, REN Chun-Sheng, YE Xiao-Lei, WANG Yi, GUO Xiao-Juan. Association between skin lesions and 8-OHdG among a chronic arsenic exposure population. CHINA ENVIRONMENTAL SCIENCECE, 2010, 30(1): 99-103.
