Abstract:In order to investigate RAR agonistic activity in aqueous environment, water samples were collected from Qing River, Beijing in each month from March to July, 2009. Water samples were extracted by solid-phase extract cartridges and their RAR agonistic activities were tested by RARα yeast two-hybrid bioassay. A further identification of environmental retinoids was carried out using high-performance liquid chromatography. Samples from some locations both upstream and downstream of the sewage treatment plant exhibited unexpectedly high RAR a agonistic activities, and the variation of agonistic activity was random. Identification of causal chemicals suggested that all-trans-4-oxo-RA and 13-cis-4-oxo-RA contributed a small part to the RAR a agonistic activity, and there are still unknown RARα agonists in Qing River.
刘俊, 沈路路, 巫晓琴, 胡建英. 北京市清河维A酸受体活性调查及原因物质解析[J]. 中国环境科学, 2010, 30(8): 1038-1043.
LIU Jun, SHEN Lu-Lu, WU Xiao-Qin, HU Jian-Ying. Occurrence and identification of environmental retinoids in Qing River, Beijing. CHINA ENVIRONMENTAL SCIENCECE, 2010, 30(8): 1038-1043.