Abstract:The reproduction and embryonic development toxicities of 1,2,4-TCB on zebrafish embryos were examined using a zebrafish embryo test. The results showed that 1,2,4-TCB presented remarkably toxicity effects on zebrafish embryos and larve. High concentration of 1,2,4-TCB(>5mg/L) showed toxic effects to embryo development, which caused the embryo abnormality, embryo aggregation and death. The embryo lethality rates were increased by 1,2,4-TCB exposure in the time-response manners and concentration-dependent ways for both adult zebrafish exposure groups and fertilized eggs exposure groups. Exposure to higher concentration of 1,2,4-TCB (15mg/L) for the adult zebrafish, the amounts of spawns and fertilization rates were decreased, and the offspring embryo lethality rates were lower than the fertilized eggs exposure groups. The ratios of typical embryo abnormality— pericardial edema and axial malformation for zebrafish embryos exposure to 1.2.4-TCB were increased with the treated concentrations. The non-lethal embryo abnormality rates in fertilized eggs exposure groups were higher than that in the adult zebrafish exposure groups at the same concentrations of 1,2,4-TCB exposure. The results indicated that 1,2,4-TCB residue in water would have potential hazard to the fish reproduction and development of fish.
杜青平, 刘伍香, 袁保红, 贾晓珊. 1,2,4-三氯苯对斑马鱼生殖和胚胎发育毒性效应[J]. 中国环境科学, 2012, 32(4): 736-741.
DU Qing-Ping, LIU Wu-Xiang, YUAN Bao-Hong, JIA Xiao-Shan. Reproduction and embryonic development toxicity of 1,2,4-TCB on zebrafish embryos. CHINA ENVIRONMENTAL SCIENCECE, 2012, 32(4): 736-741.