Abstract:To investigate the oxidative damage of brain and the effects on learning and memory ability induced by butylbenzyl phthalate (BBP) in mice. Twenty-four male Kun Ming (KM) mice were randomly assigned into 4 groups (n=6), exposed to different concentrations of BBP (0, 50, 250 and 1250 mg/kg) by oral gavage for fourteen days. During the exposure period, the Morris water maze was used to test the learning and memory abilities. After Morris water maze test the experimental animals were ended lives, and then the reactive oxygen species (ROS) level, malondialdehyde (MDA) and glutathione (GSH) contents of brains, liver and kidney were measured. BBP caused significant differences in the abilities of learning and memory at 1250mg/kg by the Morris water maze (P<0.05). Along with the increase of BBP concentrations, increased ROS level, MDA content, and reduced GSH content were observed. BBP could induce oxidative damage in brains, liver and kidney of mice, and have negative effects on the abilities of learning and memory.
刘锋明, 刘旭东, 闵安娜, 赵莉琴, 叶染枫, 李慧, 张玉超, 陈明清, 杨旭. 邻苯二甲酸丁基苄酯对小鼠学习和记忆能力的影响[J]. 中国环境科学, 2013, 33(6): 1106-1112.
LIU Feng-Ming, LIU Xu-Dong, MIN An-Na, ZHAO Li-Qin, YE Ran-Feng, LI Hui, ZHANG Yu-Chao, CHEN Ming-Qing, YANG Xu. Effects of butylbenzyl phthalate on learning and memory in mice.. CHINA ENVIRONMENTAL SCIENCECE, 2013, 33(6): 1106-1112.