Abstract:A rapid recombinant human thyroid hormone receptor (hTR) gene yeast bioassay was used to evaluate the thyroid disrupting effects in the water from the Guanting Reservoir (GR), Beijing, China. Furthermore, the geographic and seasonal distribution, and thyroid disrupting chemicals (TDCs) composition characteristics of water were analysed. The results revealed that water samples had TR antagonistic activities. The Guanting Reservoir water displayed a low to moderate effect on thyroid hormone signalling, which was impacted by the input river. The effects of the input river were significantly affected by season, so the effects of reservoir water were temporally variable. A solid phase extraction by C18cartridges was used to separate the organic extracts, which eliminated 61.9%~92.3% antagonistic activities, suggesting the organic extracts may play a major role in the TR disruption effect of the water. After addition of EDTA (30mg/L) to the residual water samples, the antagonistic activities decreased significantly, showing the metals might contribute to the TR antagonistic activity.
李剑, 任姝娟, 李沫蕊, 王亚飞. 北京官厅水库水体甲状腺激素干扰效应检测及特征[J]. 中国环境科学, 2014, 34(7): 1884-1889.
LI Jian, REN Shu-Juan, LI Mo-Rui, WANG Ya-Fei. Thyroid disrupting effects characterization of water from Guanting Reservoir, Beijing, China. CHINA ENVIRONMENTAL SCIENCECE, 2014, 34(7): 1884-1889.