Abstract：A derivatization UPLC-MS-MS method was used to analyze bisphenol A (BPA) and its chlorinated derivatives, including monochloro-BPA, dichloro-BPA, tricholro-BPA, and tetrachloro-BPA, in 40urine samples of Beijing women. The detection frequencies of BPA, monochloro-BPA, dichloro-BPA, tricholro-BPA, and tetrachloro-BPA were 90%, 96%, 90%, 52%, and 45% with average concentrations of (1.30±1.24), (0.40±0.37), (0.41±0.51), (0.18±1.49), (0.46±0.35) ng/mL, respectively. While the total concentration of four chlorinated BPA was 1.45ng/mL, which was similar with that of BPA in urine, their BPA toxic equivalent quantity (TEQBaP) in urine was calculated to be 4.84ng/mL, which was 2.2 fold higher than that of BPA. The TEQBPA concentration was log-normally distributed, and the probability higher than Benchmark Dose (BMDL0.05), corresponding to the increasing risk of diabetes by 0.05% due to exposure to BPA, was 19.2%. Our results indicated that chlorinated BPA might pose a relatively high risk.
陈默, 范湛蓝, 高群, 高福梅, 牟迪, 胡建英. 北京女性尿液中双酚A及氯代双酚A的浓度和风险评价[J]. 中国环境科学, 2015, 35(9): 2853-2860.
CHEN Mo, FAN Zhan-蓝, GAO Qun, GAO Fu-Mei, MOU Di, HU Jian-Ying. Levels and risk assessment of bisphenol A and chlorinated BPAs in urine samples of Beijing women. CHINA ENVIRONMENTAL SCIENCECE, 2015, 35(9): 2853-2860.
