Abstract:This paper explores the principles and approaches of building the indicator system for regional comprehensive environmental health risk assessment, estimates the comprehensive risks by provinces, therefore provides scientific basis for regional policies. The research applied Pressure-State-Response model to build an indicator system for comprehensive environmental health risk assessment with 23 indicators and their weight coefficients, using Analytic Hierarchy Process combined with principal component analysis and independence analysis. It was empirically tested by the 2012 data of 31 provinces, and a clustering analysis was conducted to reveal the similarity patterns and differences of regional risks. This research shows environmental health risks in 9 provinces are above the standards, developed regions (Beijing, Tianjin, Shanghai) and underdeveloped regions have comparatively low risks, and high risks are discovered in quickly developing regions. The indicators developed in regional comprehensive environmental quality assessment are rational and practical, and can be applied to other researches.