Abstract：In order to study the adjacent benzene two formic acid di isononyl ester (DINP) and adjacent benzene dicarboxylic acid diisodecyl ester (DIDP) combined exposure toxicity effect on immune system in mice with and without cooperativity. The 56SPF BALB/c mice, were randomly divided into 7groups, with the different mass ratio of DIDP and DINP mix of chemicals at the same concentration (200mg/kg) on mice were intragastric exposure, the period was 28days. After the end of exposure, the ear tissues were taken to measure the ear swelling index and ear weight differences. The tissues and serum were taken to detect the biological factors IFN-γ, IgE, IL-4and so on. The experimental results showed that the combined exposure of DIDP and DINP made the skin inflammation of mice significantly increased (P<0.01), and with the increase of the proportion of DINP, the immune toxicity gradually increased. This suggested that DIDP and DINP were associated with an immune system that was toxic to mice. However, when the combined exposure, each index was presented increasing or decreasing trend regularly, did not appear in a certain proportion of the phenomenon of strengthening or weakening of the immune toxicity. This suggested that DIDP and DINP did not have antagonistic or synergistic effects when combined with exposure.
曹昕伟, 刘潇童, 范宏成, 黄鑫, 郭彦彦, 沈世萍, 丁书茂. DIDP和DINP暴露对小鼠的免疫毒性作用[J]. 中国环境科学, 2017, 37(2): 740-744.
CAO Xin-wei, LIU Xiao-tong, FAN Hong-cheng, HUANG Xin, GUO Yan-yan, SHEN Shi-ping, DING Shu-mao. Effect of combined exposure of DIDP and DINP on the immune toxicity in mice. CHINA ENVIRONMENTAL SCIENCECE, 2017, 37(2): 740-744.
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