Treatment of waste diclofenac sodium medicine by base-catalyzed hydrothermal oxidation method
SHI Rui1,2, ZHANG Fu-Shen1,2
1. Department of Solid Waste Treatment and Recycling, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China
Aiming at the problem of lacking of green treatment technologies for pharmaceutical wastes, the current study was carried out to investigate the detoxification effect of base-catalyzed hydrothermal oxidation on diclofenac sodium (DS) medicine. The corresponding operation method was established and the reaction parameters were optimized. The suitable experimental levels were determined by single-factor design, and response surface methodology (RSM) was carried out to further establish the optimum conditions under multi-factor interaction. The results showed that base-catalyzed hydrothermal oxidation was an efficient approach for the detoxification of DS by dechlorination. The optimal parameters were, H2O2: DS 0.3mL/mg, reaction time 98min, reaction temperature 196℃, respectively. It was noted that the determined value was 98.9% and the predicted value was 99.6% with a relative error of 0.70%. Determination and analysis of the degradation products showed that there were two different reaction pathways for the degradation of DS by base-catalyzed hydrothermal oxidation: (1) the C-N bond between the two benzene rings cleaved, followed by benzene rings opened and dechlorinated through oxidation; (2) the benzene rings directly hydroxylated, followed by benzene rings opened and dechlorinated through oxidation. This study provides a green and environmentally benign approach for the detoxification of waste DS medicine.
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