二噁英暴露对成年男性血清类固醇激素的影响

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Abstract In order to investigate effect of dioxin exposure on serum steroid hormones in adult male, 17dioxin congeners of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and 9 steroid hormones were analyzed in serum from dioxin polluted area (n=50) and non-polluted area(n=48) by HRGC/HRMS and LC-MS/MS. The results showed that testosterone, estradiol, dihydrotestosterone (DHT), and dihydroepiandrosteron levels were significantly related to concentrations of several dioxin derivatives. Levels of DHT, Testosterone and Estradiol increased significantly with age in the dioxin polluted area adult males. Our findings suggest that dioxin exposure can lead to abnormal changes in sex hormones in adult male.

Key words： dioxin serum steroid hormones adult male

Received: 03 December 2017

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Corresponding Authors: 孙献亮,讲师,syh9012881999@163.com E-mail: syh9012881999@163.com

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	Articles by authors
	SHEN Bin
	SHI Li-li
	DONG Jing-jian
	FENG Hao
	SHEN Lin-jie
	XIANG Jing
	LI Wen-jing
	LUO Ting
	KIDO Teruhiko
	SUN Xian-liang

Cite this article:

SHEN Bin,SHI Li-li,DONG Jing-jian等. Effect of dioxin exposure on serum steroid hormones in adult male[J]. CHINA ENVIRONMENTAL SCIENCECE, 2018, 38(6): 2345-2352.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2018/V38/I6/2345

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