NO<sub>2</sub>对高血压患者血压和脉压的短期影响

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Abstract In order to explore the short-term effects of gaseous pollutants (NO₂) on blood pressure (BP) and pulse pressure (PP) in patients with hypertension, the NO₂ monitoring data and meteorological observation data were collected from January 1, 2011 to November 30, 2015 in Jinchang, Gansu Province. After controlling the random effect and other confounding factors, a mixed-effect model was used to analyze the association between NO₂ and BP and PP in hypertensive patients based on a prospective cohort study. The results showed that: (1) An interquartile range (IQR) increase in NO₂ at lag 1day was associated with a 0.457mmHg (95%CI: 0.131~0.784) increase in systolic blood pressure (SBP); with each IQR increase of NO₂, diastolic blood pressure (DBP) at lag 7 day and pulse pressure (PP) at lag 4 day increased 0.276mmHg (95%CI:0.025~0.527) and 0.402mmHg (95%CI:0.047~0.758), respectively. All the results was statistically significant. (2) Gender, age, BMI, smoking, drinking, and season may modify the effects of NO₂ on BP and PP among hypertensive patients. The effects of NO₂ on BP and PP remained consistent with the results in the multi-pollutant model or after adjusting dust weather.

Key words： NO₂ hypertensive patients mixed-effect model Jinchang cohort

Received: 24 December 2019

PACS:

X503.1

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	Articles by authors
	SHI Qin
	ZHENG Shan
	ZHU Wen-zhi
	WANG Min-zhen
	MIAO Qian
	LUO Yan
	NIE Yong-hong
	WENG Jun
	LI Hai-yan
	BAI Ya-na

Cite this article:

SHI Qin,ZHENG Shan,ZHU Wen-zhi等. The short-term effects of NO₂ on blood pressure and pulse pressure in patients with hypertension[J]. CHINA ENVIRONMENTAL SCIENCECE, 2020, 40(8): 3627-3635.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2020/V40/I8/3627

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