“鸡尾酒”式混合抗生素对细菌耐药性的影响

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Abstract Three kinds of commonly used antibiotics, i.e., tetracyclines, sulfonamides, and sulfonamide potentiators, were selected as representatives to obtain their concentration for the hormetic maximum promoting effect on Escherichia coli (E. coli) (HC_max). The binary and ternary mixtures of test antibiotics were designed based on equal HC_max rations, and their combined effects on bacterial growth and resistance (mutation and plasmid conjugation) of E. coli were explored. The results showed binary mixtures synergistically inhibited the growth and conjugation frequency, but synergistically stimulated the mutation frequency. The combined effects of ternary mixtures on toxicity and resistance were all synergistic inhibition. Therefore, it could be speculated that binary mixtures might increase the risk of toxicity and resistance, while ternary mixtures might result in an increased toxicity risk but a decreased resistance risk.

Key words： antibiotic mixtures bacterial resistance hormesis mutation conjugation transfer

Received: 04 June 2021

PACS:

X171.5

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	Articles by authors
	HAN Bao-cang
	CHEN Zhi-bin
	ZHANG Yue-heng
	LIN Zhi-fen
	SUN Hao-yu

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HAN Bao-cang,CHEN Zhi-bin,ZHANG Yue-heng等. The effects of antibiotic mixtures on bacterial resistance based on “cocktail” exposure[J]. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(1): 434-443.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2022/V42/I1/434

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