镉对孕鼠胎盘激素合成功能的毒性效应

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Abstract This study explored the toxic effects of low-dose maternal cadmium (Cd) exposure on the levels of estriol, progesterone and their substrates in the mouse serum and placentas. The mRNA levels of the genes involved in the hormone production were also examined by quantitative real-time PCR. The results showed that the concentration of progesterone, but not estriol, was significantly decreased by 43% and 13% respectively in the serum and placentas from the Cd-exposed mice, despite that the level of substrate for progesterone production remained unchanged in the placentas. The mRNA expression levels of progesterone synthase HSD3B6 gene and its regulatory gene D3 were significantly decreased by 73% and 85% in the Cd-exposed placentas respectively. In conclusion, low-dose maternal Cd exposure can inhibit the progesterone production in the placentas, which is likely to be due to the decrease in the expressions of hormone gene related to the hormone synthesis, such as HSD3B6 and D3.

Key words： maternal exposure placenta estriol progesterone cadmium

Received: 17 July 2021

PACS:

X174

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	Articles by authors
	XU Peng
	GUO Jing
	LI Zi-yan
	REN Huan
	JIN Ya-ling
	WANG Feng
	DU Hong-li
	LI Zhi-lang
	LIU Ming
	LI Shao-qin
	ZHAO Mei-rong
	WANG Lan

Cite this article:

XU Peng,GUO Jing,LI Zi-yan等. The toxic effects of maternal cadmium exposure on the hormone production of the mouse placentas[J]. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(3): 1359-1368.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2022/V42/I3/1359

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