PM<sub>10</sub>短期暴露对人群空腹血糖和血脂的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (696 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract This study was designed to explore the effects of short-term exposure to PM₁₀ on fasting plasma glucose and blood lipids in population with different glucose metabolism levels based on the platform of "Jinchang Cohort". The pollutant and meteorological data in Jinchang city from 2011 to 2017 were collected. Individual exposure levels were estimated by the nearest neighbor model. Generalized estimating equations were employed to analyze relationships between PM₁₀, blood glucose and blood lipids. The exposure-response relationship curves were drawn by generalized additive mixed model. For every IQR increase in PM₁₀ concentration, it was found that FPG, TC, LDL-C and HDL-C increased by 0.58mg/dL (95%CI:0.35, 0.82), 0.38mg/dL (95%CI:0.25, 0.52), 0.44mg/dL (95%CI:0.31, 0.57) and 0.34mg/dL (95%CI:0.29, 0.40), respectively, TG decreased by 0.67mg/dL (95%CI:-0.86,-0.47). With the increase of PM₁₀ concentration, FPG, TC, LDL-C and HDL-C all showed an upward trend, while TG showed a downward trend. The adverse effects of PM₁₀ on blood glucose and lipid indicators were greater in male and elder people. Findings suggest that PM₁₀ was associated with changed fasting plasma glucose and blood lipid levels among population with different blood glucose states. Male and elder people should pay more attention to personal safety protection.

Key words： PM₁₀ Type 2 diabetes fasting plasma glucose blood lipid

Received: 15 November 2021

PACS:

X503.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HE Ying-qian
	WANG Min-zhen
	ZHENG Shan
	ZHAO Ya-nan
	ZHANG Lu-lu
	LIU Jing
	BAI Ya-na

Cite this article:

HE Ying-qian,WANG Min-zhen,ZHENG Shan等. Effects of short-term exposure to PM₁₀ on fasting plasma glucose and blood lipids[J]. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(6): 2911-2920.

URL:

http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2022/V42/I6/2911

[1]	IDF Diabetes Atlas:Diabetes around the world in 2021. International Diabetes Federation[EB/OL]. http://www.diabetesatlas.org/,[2021-12-06/2022-04-11].
[2]	Eze I C, Schaffner E, Fischer E, et al. Long-term air pollution exposure and diabetes in a population-based Swiss cohort[J]. Environment International, 2014,70:95-105.
[3]	Strak M, Janssen N, Beelen R, et al. Long-term exposure to particulate matter, NO2 and the oxidative potential of particulates and diabetes prevalence in a large national health survey[J]. Environment International, 2017,108:228-236.
[4]	Liu C, Yang C, Zhao Y, et al. Associations between long-term exposure to ambient particulate air pollution and type 2 diabetes prevalence, blood glucose and glycosylated hemoglobin levels in China[J]. Environment International, 2016,92-93:416-421.
[5]	Liang F, Yang X, Liu F, et al. Long-term exposure to ambient fine particulate matter and incidence of diabetes in China:A cohort study[J]. Environment International, 2019,126:568-575.
[6]	Cui J, Sun J, Wang W, et al. The association of triglycerides and total cholesterol concentrations with newly diagnosed diabetes in adults in China[J]. Oncotarget, 2017,8(61):103477-103485.
[7]	Moro E, Gallina P, Pais M, et al. Hypertrigly ceridemia is associated with increased insulin resistance in subjects with normal glucose tolerance:Evaluation in a large cohort of subjects assessed with the 1999 World Health Organization criteria for the classification of diabetes[J]. Metabolism, 2003,52(5):616-619.
[8]	Shanley R P, Hayes R B, Cromar K R, et al. Particulate air pollution and clinical cardiovascular disease risk factors[J]. Epidemiology, 2016,27(2):291-298.
[9]	Paoin K, Ueda K, Vathesatogkit P, et al. Long-term air pollution exposure and serum lipids and blood sugar:A longitudinal cohort study from the electricity generating authority of Thailand study[J]. Atmospheric Environment, 2021,236:113790.
[10]	冉利群.金昌市人居环境空气质量评价及预测研究[D].兰州:兰州大学, 2013.Ran L Q. The assessment and prediction of living environmental air quality in Jinchang City[D]. Lanzhou:Lanzhou University, 2013.
[11]	王文路.甘肃省城市环境空气质量2005~2014年(10年)变化趋势研究[D].兰州:兰州大学, 2016.Wang W L. The change trend of urban ambient air quality from 2005 to 2014(10years) in Gansu Province[D]. Lanzhou:Lanzhou University, 2016.
[12]	丁杰萍,张亚群,周静,等.甘肃省主要城市环境空气质量变化趋势分析研究[J].甘肃科技, 2018,34(14):1-4,128.Ding J P, Zhang Y Q, Zhou J, et al. Trend analysis of environmental air quality in major cities in Gansu Province[J]. Gansu Science and Technology, 2018,34(14):1-4,128.
[13]	Bai Y, Yang A, Pu H, et al. Cohort profile:The China metal-exposed workers cohort study (Jinchang cohort)[J]. International Journal of Epidemiology, 2017,46(4):1095-1096e.
[14]	Xu X, Hu H, Ha S, et al. Ambient air pollution and hypertensive disorder of pregnancy[J]. Journal of Epidemiology and Community Health, 2014,68(1):13-20.
[15]	曹蕾,王婷,王丽君,等.邯郸市妇女空气污染暴露与妊娠期高血压[J].中国环境科学, 2021,21(2):161-164.Cao L, Wang T, Wang L J, et al. Maternal exposure to ambient air pollution and gestational hypertension in Handan[J]. China Environmental Science, 2021,21(2):161-164.
[16]	施淼,刘超斌,陈晓秋,等.大气可吸入颗粒物暴露致胎儿畸形的病例对照研究[J].中华围产医学杂志, 2013,16(4):200-205.Shi M, Liu C B, Chen X Q, et al. Fetal congenital deformity resulting from ambient inhalable particulate matters:A case-control study[J]. Chinese Journal of Perinatal Medicine, 2013,16(4):200-205.
[17]	American Diabetes Association 2. Classification and diagnosis of diabetes:standards of medical care in diabetes-2019[J]. Diabetes Care, 2019,42(Suppl 1):S13-S28.
[18]	刘力生.中国高血压防治指南(2018年修订版)[J].中国心血管杂志, 2019,24(1):24-55.Liu L S. 2018 Chinese guidelines for the management of hypertension[J]. Chinese Journal of Cardiovascular Medicine, 2019,24(1):24-55.
[19]	诸骏仁,高润霖,赵水平,等.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志, 2016,31(10):937-953.Chu J R, Gao R L, Zhao S P. 2016Chinese guidelines for the management of dyslipidemia in adults[J]. Chinese Circulation Journal, 2016,31(10):937-953.
[20]	Chen L, Zhou Y, Li S, et al. Air pollution and fasting blood glucose:A longitudinal study in China[J]. Science of The Total Environment, 2016,541:750-755.
[21]	Guo P, Feng W, Zheng M, et al. Short-term associations of ambient air pollution and cause-specific emergency department visits in Guangzhou, China[J]. Science of The Total Environment, 2018,613-614:306-313.
[22]	Zhang W, Wang Y, Li W, et al. The Association between the baseline and the change in neutrophil-to-lymphocyte ratio and short-term mortality in patients with acute respiratory distress syndrome[J]. Frontiers in Medicine, 2021,8:636869.
[23]	Cai Y, Hansell A L, Blangiardo M, et al. Long-term exposure to road traffic noise, ambient air pollution, and cardiovascular risk factors in the HUNT and lifelines cohorts[J]. European Heart Journal, 2017, 38(29):2290-2296.
[24]	Chuang K J, Yan Y H, Cheng T J. Effect of air pollution on blood pressure, blood lipids, and blood sugar:A population-based approach[J]. Journal of Occupational and Environmental Medicine, 2010,52(3):258-262.
[25]	Mao S, Chen G, Liu F, et al. Long-term effects of ambient air pollutants to blood lipids and dyslipidemias in a Chinese rural population[J]. Environmental Pollution, 2020,256(C):113403.
[26]	Poursafa P, Mansourian M, Motlagh M E, et al. Is air quality index associated with cardiometabolic risk factors in adolescents?The CASPIAN-III Study[J]. Environmental Research, 2014,134:105-109.
[27]	Yitshak Sade M, Kloog I, Liberty I F, et al. The association between air pollution exposure and glucose and lipids levels[J]. The Journal of Clinical Endocrinology and Metabolism, 2016,101(6):2460-2467.
[28]	Gui Z H, Yang B Y, Zou Z Y, et al. Exposure to ambient air pollution and blood lipids in children and adolescents:A national population based study in China[J]. Environmental Pollution, 2020,266(Pt 3):115422.
[29]	Bind M A, Peters A, Koutrakis P, et al. Quantile regression analysis of the distributional effects of air pollution on blood pressure, heart rate variability, blood lipids, and biomarkers of inflammation in elderly American men:The normative aging study[J]. Environmental Health Perspectives, 2016,124(8):1189-1198.
[30]	Rajagopalan S, Brook R D. Air pollution and type 2diabetes:Mechanistic insights[J]. Diabetes, 2012,61(12):3037-3045.
[31]	Bourdrel T, Bind M A, Bejot Y, et al. Cardiovascular effects of air pollution[J]. Archives of Cardiovascular Diseases, 2017,110(11):634-642.
[32]	Yang B Y, Bloom M S, Markevych I, et al. Exposure to ambient air pollution and blood lipids in adults:The 33Communities Chinese Health Study[J]. Environment International, 2018,119:485-492.
[33]	Brook R D, Rajagopalan S, Pope C A, et al. Particulate matter air pollution and cardiovascular disease:An update to the scientific statement from the American Heart Association[J]. Circulation, 2010,121(21):2331-2378.
[34]	Chen R, Meng X, Zhao A, et al. DNA hypomethylation and its mediation in the effects of fine particulate air pollution on cardiovascular biomarkers:A randomized crossover trial[J]. Environment International, 2016,94:614-619.
[35]	Li H, Chen R, Cai J, et al. Short-term exposure to fine particulate air pollution and genome-wide DNA methylation:A randomized, double-blind, crossover trial[J]. Environment International, 2018,120:130-136.
[36]	Shin W Y, Kim J H, Lee G, et al. Exposure to ambient fine particulate matter is associated with changes in fasting glucose and lipid profiles:A nationwide cohort study[J]. BMC Public Health, 2020,20(1):430.
[37]	Wang B, Xu D, Jing Z, et al. Effect of long-term exposure to air pollution on type 2diabetes mellitus risk:A systemic review and meta-analysis of cohort studies[J]. European Journal of Endocrinology, 2014,171(5):R173-182.
[38]	Zhang K, Wang H, He W, et al. The association between ambient air pollution and blood lipids:A longitudinal study in Shijiazhuang, China[J]. Science of The Total Environment, 2021,752:141648.
[39]	Sorensen M, Hjortebjerg D, Eriksen K T, et al. Exposure to long-term air pollution and road traffic noise in relation to cholesterol:A cross-sectional study[J]. Environment International, 2015,85:238-243.
[40]	Lin H, Guo Y, Zheng Y, et al. Long-term effects of ambient PM2.5on hypertension and blood pressure and attributable risk among older chinese adults[J]. Hypertension, 2017,69(5):806-812.
[41]	Zhang X, Yu B, He T, et al. Status and determinants of health services utilization among elderly migrants in China[J]. Global Health Research and Policy, 2018,3(6):8.