基于可疑筛查技术研究有机磷阻燃剂V6转化规律

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Abstract This study studied metabolism of V6 in human liver microsomes (HLM) using Orbitrap high-resolution mass spectrometer (Orbitrap-HRMS). With the exception of 5 reported metabolites including O-dealkylated, oxidative de-phospherylated and O- dechlorinated compounds, 6 novel products were firstly observed. Based on their MS/MS spectra, these newly discovered metabolites were identified as aldehyde and carboxyl products. Of them, 5 metabolites can be accumulative according to their linearly increasing tendency in vitro experiment. In addition, the proposed metabolic pathway demonstrated the primarily metabolites, i.e. dealkylated and hydroxylated metabolites were further transformed into secondary metabolites, i.e., aldehyde and carboxyl metabolites.

Key words： organophosphate flame retardant of emerging concern human liver microsomes high-resolution mass spectrometer metabolism in vitro biotransformation rule

Received: 25 February 2022

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X503.2

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	LI Jian-hua
	ZHANG Ya-yun
	MENG Wei-kun
	SU Guan-yong

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LI Jian-hua,ZHANG Ya-yun,MENG Wei-kun等. Biotransformation of an organophosphate flame retardant V6 based on suspect screening technique[J]. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(9): 4409-4415.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2022/V42/I9/4409

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