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| Effect of chronic noise-exposure on liver lipid metabolism in high-fat diet mice |
| XU Dan1, CAO Shuang-feng2, LIU Li-jie1,3 |
1. School of Public Health, Southeast University, Nanjing 210009, China;
2. School of Life Science and Technology, Southeast University, Nanjing 210096, China;
3. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Medical College, Southeast University, Nanjing 210009, China |
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Abstract To explore the effect of chronic noise-exposure on liver lipid metabolism, C57BL/6J mice were randomly divided into control group and noise exposure group (85dB(A) SPL broad-band noise, 4h/d, for 8weeks). Each group was divided into two subgroups that were given a chow diet or a high-fat diet. The body weight growth rate, glucose tolerance, insulin tolerance, the epididymal fat weight, liver weight, the levels of serum interleukin-6, the levels of serum triglyceride and total cholesterol, the levels of triglyceride and total cholesterol in liver, the levels of malonaldehyde in liver and the phosphorylation levels of c-Jun N-terminal kinase in liver of mice were measured at the end of experiment. The results show that noise exposure can significantly decrease the body weight growth rate (23.30±2.54%vs. 37.13±3.05%), significantly increase the metabolic efficiency (545.20±55.06kJ/g/mouse vs. 352.50±20.92kJ/g/mouse) and the levels of serum interleukin-6 (44.68±9.77pg/mL vs. 20.83±0.81pg/mL) of mice fed by chow diet. That noise exposure can significantly increase the levels of triglyceride (0.54±0.07mmol/g protein vs. 0.30±0.03mmol/g protein) and malondialdehyde (1.98±0.13nmol/mg protein vs. 1.24±0.03nmol/mg protein) and the phosphorylation levels of c-Jun N-terminal kinase (1.56±0.19vs. 1.00±0.00) in liver of mice fed by high fat diet. In conclusion, in this study chronic noise exposure can aggravate liver lipid metabolism disorders in high-fat-diet mice, and the activation of c-Jun N-terminal kinase may be involved in the liver lipid metabolism disorders.
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Received: 25 July 2022
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