母婴PFASs靶向与非靶向分析及新生儿健康风险

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (602 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 50 paired samples of maternal and newborn serum, as well as placenta were collected from pregnant women at delivery around Fuxin fluorochemical facilities, and all the samples were analyzed through the target and non-target screening strategies. In the target analysis, 21 legacy per- and polyfluoroalkyl substances (PFASs) in the whole samples were analyzed through high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), revealing that perfluorobutane sulfonate (PFBS), perfluorobutanoic acid (PFBA), and perfluorooctanoic acid (PFOA) were the dominant PFAS contaminants observed in all the samples. In the suspect screening based upon high-resolution mass spectrometry (HRMS), 49 novel PFASs in 11classes were identified in the Fuxin samples, and 20 novel congeners assigned to 4 classes were determined in human sera and placentas for the first time. In addition, the coefficients for mother-placenta transfer (R_m/p) and mother-newborn transfer (R_m/n) of legacy PFASs could be estimated with the median values of 1.7 and 2.0 individually, and R_m/pand R_m/nof novel PFASs were also calculated with the median values of 0.9 and 0.8, respectively. Accordingly, the average contribution rate of all novel PFASs increased from 90% in maternal serum to 96% in neonatal serum. Moreover, the linear regression analysis determined significant correlations among the neonatal growth parameters (gestation and head circumferences of newborns) and serum levels of thyroid hormone, sex hormone, and glucocorticoid, together with the levels of certain legacy and novel PFASs in neonatal sera, and the most representative compounds included perfluorocarboxylic acids (PFCAs), perfluorosulfonic acids (PFSAs), H-substituted perfluorocarboxylic acids (H-PFCAs), H-substituted perfluorosulfonic acids (H-PFSAs), and chlorinated polyfluorinated ether sulfonates (Cl-PFESAs). The results above demonstrated that legacy and novel PFASs could potentially contribute to certain health risks of newborns.

Key words： per-and polyfluoroalkyl substances (PFASs) target analysis non-target screening placental transfer prenatal exposure health risk

Received: 02 December 2022

PACS:

X503.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	BAO Jia
	QU Wen-e
	SHAO Li-xin
	LIU Yang
	WANG Xin
	WU Yu-qing

Cite this article:

BAO Jia,QU Wen-e,SHAO Li-xin等. Target and nontarget analysis of PFASs in mothers and newborns and related health risks of newborns[J]. CHINA ENVIRONMENTAL SCIENCECE, 2023, 43(7): 3730-3740.

URL:

http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2023/V43/I7/3730

[1]	Kissa E. Fluorinated surfactants and Repellents [M]. New York: CRC Press, 2001.
[2]	金航标,祝凌燕,单国强,等.高效液相色谱-串联质谱法同时测定人血清中的全氟辛烷磺酸及其前体物 [J]. 环境化学, 2016,35(6): 1180-1188. Jin H B, Zhu L Y, Shan G Q, et al. Determination of perfluorooctane sulfonate and its precursors in human serum samples by high performance liquid chromatography electrospray tandem mass spectrometry [J]. Environmental Chemistry, 2016,35(6):1180-1188.
[3]	张春晖,刘育,唐佳伟,等.典型工业废水中全氟化合物处理技术研究进展 [J]. 中国环境科学, 2021,41(3):1109-1118. ZHANG C H, LIU Y, TANG J W, et al. Progress of research on treatment technology of perfluorinated compounds in typical industrial wastewater [J]. China Environmental Science, 2021,41(3):1109-1118.
[4]	Giesy J P, Kannan K. Global distribution of perfluorooctane sulfonate in wildlife [J]. Environmental Science & Technology, 2001,35(7): 1339-1342.
[5]	Hansen K J, Clemen L A, Ellefson M E, et al. Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices [J]. Environmental Science & Technology, 2001,35(4): 766-770.
[6]	鲍佳.典型水体沉积物与点源周边环境的全氟烷酸类化合物污染现状及趋势研究 [D]. 辽宁:大连理工大学, 2010. BAO J. Research on perfluoroalkyl acid (PFAA) contamination status and trend in the sediments of typical water bodies and the environment around a point source [D]. Dalian: Dalian University of Technology, 2010.
[7]	王振旗,龚平,王小萍,等.室内聚全氟化合物(PFCs)暴露对人体的影响 [J]. 中国环境科学, 2013,(1):192-192.
[8]	SUN D C, GONG P, WANG X P, et al. Special distribution and seasonal variation of perfluoroalkyls substances in Lhasa River Basin, China [J]. China Environmental Science, 2018,38(11):4298-4306.
[9]	Bao J, Li C L, Liu Y, et al. Bioaccumulation of perfluoroalkyl substances in greenhouse vegetables with long-term groundwater irrigation near fluorochemical plants in Fuxin, China [J]. Environmental Research, 2020a,188:109751.
[10]	Bao J, Yu W J, Liu Y, et al. Removal of perfluoroalkanesulfonic acids (PFSAs) from synthetic and natural groundwater by electrocoagulation [J]. Chemosphere, 2020b,248:125951.
[11]	Lopez-Espinosa M J, Mondal D, Armstrong B, et al. Thyroid function and perfluoroalkyl acids in children living near a chemical plant [J]. Environmental Health Perspectives, 2012,120(7):1036-1041.
[12]	张露露,刘婧,贺颖倩,等.血清全氟化合物与代谢相关脂肪性肝病患病风险的关系 [J]. 中国环境科学, 2023,43(2):964-972. ZHANG L L, LIU J, HE Y Q, et al. Relationship of serum perfluoroalkyl substances with the risk of metabolic associated fatty liver disease [J]. China Environmental Science, 2023,43(2):964-972.
[13]	林泳峰,阮挺,江桂斌.新型全氟和多氟烷基化合物的分析、行为与效应研究进展 [J]. 科学通报, 2017,62(24):2724-2738. Lin Y F, Ruan T, Jiang G B. Progress on analytical methods and environmental behavior of emerging per-and polyfluoroalkyl substances [J]. Chinese Science Bulletin, 2017,62(24):2724-2738.
[14]	Nelson J W, Hatch E E, Webster T F, et al. Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S [J]. Environmental Health Perspectives, 2010,118(2): 197-202.
[15]	Steenland K, Tinker S, Shankar A, et al. Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA [J]. Environmental Health Perspectives, 2010,118(2):229-233.
[16]	谢蕾,章涛,孙红文,等.全氟烷基化合物在人体肝脏中的富集特征及其与肝损伤的关系 [J]. 环境化学, 2020,39(6):1479-1487. XIE L, ZHANG T, SUN H W, et al. Enrichment characteristics of perfluoroalkyl substances (PFASs) in human liver and its association with hepatocyte apoptosis [J]. Environmental Chemistry, 2020,39(6): 1479-1487.
[17]	Lee Y A, Kim J H, Jung H W, et al. The serum concentrations of perfluoroalkyl compounds were inversely associated with growth parameters in 2-year-old children [J]. Science of Total Environment, 2018,628:226-232.
[18]	Harris M H, Oken E, Rifas-Shiman S L, et al. Prenatal and childhood exposure to per-and polyfluoroalkyl substances (PFASs) and child cognition [J]. Environment International, 2018,115:358-369.
[19]	Stein C R, Savitz D A. Serum perfluorinated compound concentration and attention deficit/hyperactivity disorder in children 5-18years of age [J]. Environmental Health Perspectives, 2011,119(10):1466-1471.
[20]	Stein C R, McGovern K J, Pajak A M, et al. Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12-19y: National Health and Nutrition Examination Survey [J]. Pediatric Research, 2016,79(2):348-357.
[21]	Huang H, Yu K, Zeng X, et al. Association between prenatal exposure to perfluoroalkyl substances and respiratory tract infections in preschool children [J]. Environmental Research, 2020,191:110156.
[22]	Qin X D, Qian Z M, Dharmage S C, et al. Association of perfluoroalkyl substances exposure with impaired lung function in children [J]. Environmental Research, 2017,155:15-21.
[23]	Liu H, Pan Y, Jin S, et al. Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns [J]. Environment International, 2020,140:105636.
[24]	Qin X D, Qian Z, Vaughn M G, et al. Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan [J]. Environmental Pollution, 2016,212:519-524.
[25]	Pan Y, Zhu Y, Zheng T, et al. Novel Chlorinated polyfluorinated ether sulfonates and legacy per-/polyfluoroalkyl substances: placental transfer and relationship with serum albumin and glomerular filtration rate [J]. Environmental Science & Technology, 2017,51(1):634-644.
[26]	Gao K, Zhuang T, Liu X, et al. Prenatal exposure to per-and polyfluoroalkyl substances (PFASs) and association between the placental transfer efficiencies and dissociation constant of serum proteins-PFAS complexes [J]. Environmental Science & Technology, 2019,53(11): 6529-6538.
[27]	卢昕妍,王菲,张丽敏,等.太湖西岸地表水中极性有机污染物非靶向筛查与生态风险评估 [J]. 环境科学, 2021,42(11):5284-5293. LU X Y, WANG F, ZHANG L M, et al. Nontarget screening and ecological risk assessment of polar organic pollutants in surface water on the west bank of Taihu Lake [J]. Environmental Science, 2021,42(11):5284-5293.
[28]	Ccanccapa-Cartagena A, Pico Y, Ortiz X, et al. Suspect, non-target and target screening of emerging pollutants using data independent acquisition: assessment of a Mediterranean River basin [J]. Science of Total Environment, 2019,687:355-368.
[29]	Kotlarz N, McCord J, Collier D, et al. Measurement of novel, drinking water-associated PFAS in blood from adults and children in Wilmington, North Carolina [J]. Environmental Health Perspectives, 2020,128(7):77005.
[30]	Liu Y, Qian M, Ma X, et al. Nontarget mass spectrometry reveals new perfluoroalkyl substances in fish from the Yangtze River and Tangxun Lake, China [J]. Environmental Science & Technology, 2018,52(10): 5830-5840.
[31]	Newton S, McMahen R, Stoeckel J A, et al. Novel Polyfluorinated compounds identified using high resolution mass spectrometry downstream of manufacturing facilities near Decatur, Alabama [J]. Environmental Science & Technology, 2017,51(3):1544-1552.
[32]	Plassmann M M, Schmidt M, Brack W, et al. Detecting a wide range of environmental contaminants in human blood samples-combining QuEChERS with LC-MS and GC-MS methods [J]. Analytical and Bioanalytical Chemistry, 2015,407(23):7047-7054.
[33]	Schymanski E L, Singer H P, Longrée P, et al. Strategies to characterize polar organic contamination in wastewater: exploring the capability of high resolution mass spectrometry [J]. Environmental Science & Technology, 2014,48(3):1811-1818.
[34]	Strynar M, Dagnino S, McMahen R, et al. Identification of novel perfluoroalkyl ether carboxylic acids (PFECAs) and sulfonic acids (PFESAs) in natural waters using accurate mass time-of-flight mass spectrometry (TOFMS) [J]. Environmental Science & Technology, 2015,49(19):11622-11630.
[35]	Wang Y, Yu N, Zhu X, et al. Suspect and nontarget screening of per-and polyfluoroalkyl substances in wastewater from a fluorochemical manufacturing park [J]. Environmental Science & Technology, 2018, 52(19):11007-11016.
[36]	Li Y, Yu N, Du L, et al. Transplacental transfer of per-and polyfluoroalkyl substances identified in paired maternal and cord sera using suspect and nontarget screening [J]. Environmental Science & Technology, 2020,54(6):3407-3416.
[37]	Wang A, Abrahamsson D P, Jiang T, et al. Suspect screening, prioritization, and confirmation of environmental chemicals in maternal-newborn pairs from San Francisco [J]. Environmental Science & Technology, 2021,55(8):5037-5049.
[38]	Bao J, Yu W J, Liu Y, et al. Perfluoroalkyl substances in groundwater and home-produced vegetables and eggs around a fluorochemical industrial park in China [J]. Ecotoxicology and Environmental Safety, 2019,171:199-205.
[39]	Bao J, Liu L, Wang X, et al. Human exposure to perfluoroalkyl substances near a fluorochemical industrial park in China [J]. Environmental Science and Pollution Research, 2017,24(10):9194-9201.
[40]	Bao J, Liu W, Liu L, et al. Perfluorinated compounds in the environment and the blood of residents living near fluorochemical plants in Fuxin, China [J]. Environmental Science & Technology, 2011,45(19):8075-8080.
[41]	Plassmann M M, Fischer S, Benskin J P, et al. Nontarget time trend screening in human blood [J]. Environmental Science & Technology Letters, 2018,5(6):335-340.
[42]	Wang X, Yu N, Qian Y, et al. Non-target and suspect screening of per-and polyfluoroalkyl substances in Chinese municipal wastewater treatment plants [J]. Water Research, 2020,183:115989.
[43]	Yu N, Guo H, Yang J, et al. Nontarget and suspect screening of per-and polyfluoroalkyl substances in airborne particulate matter in China [J]. Environmental Science & Technology, 2018,52(15):8205-8214.
[44]	Cao W, Liu X, Liu X, et al. Perfluoroalkyl substances in umbilical cord serum and gestational and postnatal growth in a Chinese birth cohort [J]. Environment International, 2018,116:197-205.
[45]	Chen L, Tong C, Huo X, et al. Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and birth outcomes: A longitudinal cohort with repeated measurements [J]. Chemosphere, 2021,267:128899.
[46]	Aimuzi R, Luo K, Chen Q, et al. Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery [J]. Environment International, 2019,130:104929.
[47]	Guo J, Zhang J, Wang Z, et al. Umbilical cord serum perfluoroalkyl substance mixtures in relation to thyroid function of newborns: findings from Sheyang Mini Birth Cohort Study [J]. Chemosphere, 2021,273:129664.
[48]	Liang H, Wang Z, Miao M, et al. Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort [J]. Environmental Health, 2020,19(1):1-14.
[49]	Lebeaux R M, Doherty B T, Gallagher L G, et al. Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: the HOME Study [J]. Environmental Research, 2020,185:109395.
[50]	Li Y, Xu Y, Fletcher T, et al. Associations between perfluoroalkyl substances and thyroid hormones after high exposure through drinking water [J]. Environmental Research, 2021,194:110647.
[51]	Nian M, Luo K, Luo F, et al. Association between prenatal exposure to PFAS and fetal sex hormones: are the short-chain PFAS safer [J]? Environmental Science & Technology, 2020,54(13):8291-8299.
[52]	Goudarzi H, Araki A, Itoh S, et al. The association of prenatal exposure to perfluorinated chemicals with glucocorticoid and androgenic hormones in cord blood samples: the Hokkaido Study [J]. Environmental Health Perspectives, 2017,125(1):111-118.