PM<sub>2.5</sub>及其组分短期暴露对空腹血糖和血脂的影响

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Abstract The effects of PM_2.5 and its constituents (SO₄^2-, NO₃^-, NH₄⁺, OM, BC) on fasting blood glucose and lipid levels in the short-term were examined in the “Jinchang Cohort”. The daily average concentrations of PM_2.5 and its constituents from 2010to 2015 in Jinchang City were sourced from China's Near Real-Time Air Pollutants dataset. Individual exposure was determined by matching the study subjects' residential addresses with pollution data. Generalized estimating equations were used to analyze the short-term effects of PM_2.5 and its constituents on glucose and lipid indicators. Generalized additive mixed models were used to create exposure-response curves and perform stratified analyses. The findings showed that PM_2.5 and its constituents had delayed effects on blood glucose and lipid levels. Specifically, higher concentrations of PM_2.5, SO₄^2-, NO₃^-, NH₄⁺, and OM correlated with increased levels of FPG, TC, HDL-C, and LDL-C, while TG showed a decrease. PM_2.5 and SO₄^2- exhibited more pronounced effects on fasting blood glucose levels in males, whereas PM_2.5 and its five components had more significant impacts on lipid levels in females, individuals aged 60 years or older, those who are overweight or obese, individuals in prediabetic stages, and those with hypertension. Therefore, short-term exposure to PM_2.5 and its components correlates with abnormal blood glucose and lipid levels in the population. Thus, various high-risk groups should adopt self-protection measures accordingly.

Key words： PM_2.5 and its constituents Type 2Diabetes Mellitus Fasting plasma glucose Blood lipids Cohort study

Received: 30 July 2024

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X503

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	SANG Chen
	HE Ying-qian
	JIA Jia
	CHEN Hao
	WANG Min-zhen

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SANG Chen,HE Ying-qian,JIA Jia等. Effects of short-term exposure to PM_2.5 and its constituents on fasting plasms glucose and blood lipids[J]. CHINA ENVIRONMENTAL SCIENCECE, 2025, 45(2): 1118-1126.

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http://www.zghjkx.com.cn/EN/ OR http://www.zghjkx.com.cn/EN/Y2025/V45/I2/1118

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