Occurrence and ecological risk of typical antibiotics in surface water of the Datong Lake, China
LIU Xiao-hui1,2, LU Shao-yong2
1. School of Environment, Tsinghua University, Beijing 10084, China; 2. State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu, National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria and Risk Assessment, Research Centre of Lake Environment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China
Abstract:The concentrations of 12 antibiotics.classified into sulfanilamides (SAs), trimethoprim (TMP), quinolones (QNs) and tetracyclines (TCs) in surface water of the Datong Lake, were detected by UPLC-MS/MS in order to assess the occurrence and risk level of typical antibiotics. 11 antibiotics were detected expect for ofloxacin, and the total concentrations of antibiotics ranged from 0.19ng/L to 261.89ng/L in surface water. The highest average concentration was sulfadiazine (37.41ng/L), followed by sulfamethoxazole (12.34ng/L) > sarafloxacin (8.55ng/L) > enrofloxacin (8.04ng/L) > trimethoprim (7.56ng/L) > chlortetracycline (3.92ng/L). The detection frequencies of sulfa-diazine, tetracycline, chlortetracycline, sarafloxacin, trimethoprim and sulfamethoxazole, were over 50%, could be higher than 50%. The pollution level was similar to those of other rivers and lakes in China expect for sulfadiazine and enrofloxacin. Spatially, the pollution level of antibiotics in Datong Lake showed distinct differences. The results of environmental risk assessment indicated that sulfamethoxazole, ciprofloxacin and sarafloxacin, RQ>1, might pose a significant risk to aquatic organisms of the Datong Lake. The cumulative risk of S2, S3 and S6 were higher, and the main factors were enrofloxacin and sarafloxacin, sulfamethoxazole and ciprofloxacin, ciprofloxacin and sarafloxacin, respectively. The health risk indexes for adults and children, calculated for 11 antibiotics based on the acceptable daily intake through drinking water, ranged from 8.74×10-8 to 9.17×10-3, with children having a higher index than adults.
刘晓晖, 卢少勇. 大通湖表层水体中抗生素赋存特征与风险[J]. 中国环境科学, 2018, 38(1): 320-329.
LIU Xiao-hui, LU Shao-yong. Occurrence and ecological risk of typical antibiotics in surface water of the Datong Lake, China. CHINA ENVIRONMENTAL SCIENCECE, 2018, 38(1): 320-329.
Gallardo-Godoy A, Muldoon C, Becker B, et al. Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B[J]. Journal of medicinal chemistry, 2016,59(3):1068-1077.
[3]
Wollenberger L, Halling-Sørensen B, Kusk K O. Acute and chronic toxicity of veterinary antibiotics to Daphnia magna[J]. Chemosphere, 2000,40(7):723-730.
McGowan E. Comment on "Antibiotic resistance genes as emerging contaminants:Studies in Northern Colorado"[J]. Environmental science & technology, 2007,41(7):2651-2652.
Zhang Q Q, Ying G G, Pan C G, et al. Comprehensive evaluation of antibiotics emission and fate in the river basins of China:source analysis, multimedia modeling, and linkage to bacterial resistance[J]. Environmental science & technology, 2015,49(11):6772-6782.
Eguchi K, Nagase H, Ozawa M, et al. Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae[J]. Chemosphere, 2004,57(11):1733-1738.
[12]
Ferrari B, Mons R, Vollat B, et al. Environmental risk assessment of six human pharmaceuticals:are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?[J]. Environmental Toxicology and Chemistry, 2004,23(5):1344-1354.
[13]
Bia?k-Bielińska A, Stolte S, Arning J, et al. Ecotoxicity evaluation of selected sulfonamides[J]. Chemosphere, 2011, 85(6):928-933.
[14]
Lützhøft H C H, Halling-Sørensen B, Jørgensen S E. Algal toxicity of antibacterial agents applied in Danish fish farming[J]. Archives of Environmental Contamination and Toxicology, 1999, 36(1):1-6.
[15]
Backhaus T, Scholze M, Grimme L H. The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri[J]. Aquatic toxicology, 2000,49(1):49-61.
[16]
Isidori M, Lavorgna M, Nardelli A, et al. Toxic and genotoxic evaluation of six antibiotics on non-target organisms[J]. Science of the Total Environment, 2005,346(1):87-98.
[17]
Backhaus T, Scholze M, Grimme L H. The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri[J]. Aquatic toxicology, 2000,49(1):49-61.
[18]
Robinson A A, Belden J B, Lydy M J. Toxicity of fluoroquinolone antibiotics to aquatic organisms[J]. Environmental toxicology and Chemistry, 2005,24(2):423-430.
[19]
Lützhøft H C H, Halling-Sørensen B, Jørgensen S E. Algal toxicity of antibacterial agents applied in Danish fish farming[J]. Archives of Environmental Contamination and Toxicology, 1999, 36(1):1-6.
[20]
González-Pleiter M, Gonzalo S, Rodea-Palomares I, et al. Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms:implications for environmental risk assessment[J]. Water Research, 2013,47(6):2050-2064.
[21]
Kolar B, Arnuš L, Jeretin B, et al. The toxic effect of oxytetracycline and trimethoprim in the aquatic environment[J]. Chemosphere, 2014,115:75-80.
Australian Government Department of Health.Acceptable Daily Intakes for Agricultural and Veterinary Chemicals[EB/ZL]. http://www.health.gov.au/internet/main/publishing.nsf/Content/ocs-adi-list.htm, 2016-03-31.
Xiong W, Sun Y, Zhang T, et al. Antibiotics, antibiotic resistance genes, and bacterial community composition in fresh water aquaculture environment in China[J]. Microbial ecology, 2015, 70(2):425-432.
Wang Q, Yates S R. Laboratory study of oxytetracycline degradation kinetics in animal manure and soil[J]. Journal of Agricultural and Food Chemistry, 2008,56(5):1683-1688.
[35]
Liu Y, He X, Duan X, et al. Photochemical degradation of oxytetracycline:influence of pH and role of carbonate radical[J]. Chemical Engineering Journal, 2015,276:113-121.
[36]
Wu C, Huang X, Witter J D, et al. Occurrence of pharmaceuticals and personal care products and associated environmental risks in the central and lower Yangtze river, China[J]. Ecotoxicology and environmental safety, 2014,106:19-26.
[37]
Li W H, Shi Y L, Gao L H, et al. Occurrence of antibiotics in water, sediments, aquatic plants, and animals from Baiyangdian Lake in North China[J]. Chemosphere, 2012,89:1307-1315.
[38]
Xu J, Zhang Y, Zhou C B, et al. Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake, China[J]. Science of the Total Environment, 2014,s497-498(3):267-273.
Luo Y, Xu L, Rysz M, et al. Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China[J]. Environmental Science & Technology, 2011,45(5):1827-1833.
Tamtam F, Mercier F, Le Bot B, et al. Occurrence and fate of antibiotics in the Seine River in various hydrological conditions[J]. Science of the Total Environment, 2008,393(1):84-95.
[48]
Vieno N M, Härkki H, Tuhkanen T, et al. Occurrence of pharmaceuticals in river water and their elimination in a pilotscale drinking water treatment plant[J]. Environmental Science & Technology, 2007,41(14):5077-5084.
[49]
Managaki S, Murata A, Takada H, et al. Distribution of macrolides, sulfonamides, and trimethoprim in tropical waters:ubiquitous occurrence of veterinary antibiotics in the Mekong Delta[J]. Environmental Science & Technology, 2007,41(23):8004-8010.
[50]
Arikan O A, Rice C, Codling E. Occurrence of antibiotics and hormones in a major agricultural watershed[J]. Desalination, 2008,226(1-3):121-133.
[51]
Kasprzyk-Hordern B, Dinsdale R M, Guwy A J. The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters[J]. Water research, 2009,43(2):363-380.
Gagné F, Blaise C, André C. Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes[J]. Ecotoxicology and Environmental Safety, 2006,64(3):329-336.