Research progress in male reproductive toxicity of bisphenol A analogues
LI Hong-mei1,2, XIONG Yi-ming1,2, XU Hai-ming3, LI Yuan-yuan1,2, LI Jin-bo1,2, QIN Zhan-fen1,2
1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; 2. College of Resources and Environmeal University of Chinese Academy of Sciences, Beijing 100049; 3. Department of Occupational and Environmental Hygiene, School of Public Health and Management, Ningxia Medical University, Yinchuan 750004, China
Abstract：This paper examined studies on bisphenol analogues and male reproductive toxicity with the focus on analyzing the data involving toxic effects of bisphenol analogues on the testis and organization structure, weight and histological structure of epididymis, hormone levels and sperm parameters in mammals, and investigating several essays about fish and amphibian animal research. All BPA analogues had reproductive hazards in these animals regardless of dose, mode of exposure, or species of animals, which suggested that these BPA analogues had more significant male reproductive toxicity than that of BPA on which researches were still debating. However, the majority of data points on the male reproductive toxicity of BPA analogues was limited from a few laboratories and quality control was also hard to discern. Therefore, to obtain more reliable and repeatable results, the findings on male reproductive toxicity of BPA analogues need to be verified by more laboratories, and the quality of animal experiments should be strictly controlled.
李红梅, 熊忆茗, 徐海明, 李圆圆, 李金波, 秦占芬. 双酚A类似物的雄性生殖毒性研究进展[J]. 中国环境科学, 2021, 41(6): 2939-2945.
LI Hong-mei, XIONG Yi-ming, XU Hai-ming, LI Yuan-yuan, LI Jin-bo, QIN Zhan-fen. Research progress in male reproductive toxicity of bisphenol A analogues. CHINA ENVIRONMENTAL SCIENCECE, 2021, 41(6): 2939-2945.
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