PFAS混合暴露与高尿酸血症关联性研究

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摘要为评估全氟和多氟烷基物质(PFAS)及其混合物对高尿酸血症(HUA)的关联及综合效应并识别其中的关键组分,基于美国国家健康和营养检查调查(NHANES)数据,使用Logistic回归、加权分位数和回归、贝叶斯核机器回归对2013~2016年2564名研究对象进行分析.当PFAS作为单一污染源暴露时,较高水平的全氟烷基壬酸(PFNA)、直链全氟烷基辛酸(n-PFOA)和单甲基支链全氟辛烷磺酸异构体(Sm-PFOS)与HUA存在正向关联(P<0.05).将其视为混合物暴露时,PFAS混合物与HUA总体呈正相关,PFAS混合物(WQS指数)每增加一个四分位数,HUA患病风险增加39.6%(OR=1.396, 95%CI:1.180~1.651,P<0.001),且这种关联仅存在于女性人群中.n-PFOA和Sm-PFOS是其中的关键组分,直链全氟辛烷磺酸(n-PFOS)和全氟己烷磺酸(PFHxS)在混合物中可能与HUA呈负相关,多种PFAS之间可能存在潜在的交互作用.研究结果可为PFAS与高尿酸血症患病风险研究提供最新流行病学证据,为重点人群筛查提供依据.

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关键词 ：高尿酸血症, 全氟和多氟烷基物质, 混合物, 贝叶斯核机器回归, 加权分位数和回归

Abstract：To evaluate the association and combined effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and mixtures on hyperuricemia (HUA) and identify key components, this study analyzed data from 2,564 subjects in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 using logistic regression, weighted quantile sum regression, and Bayesian kernel machine regression. Higher levels of perfluorononanoic acid (PFNA), n-perfluorooctane sulfonic acid (n-PFOA), and perfluoromethylheptane sulfonic acid isomers (Sm-PFOS) were positively associated with HUA when PFAS was exposed as a single source (P<0.05). When considered as mixture exposure, PFAS mixtures were positively associated with HUA overall, with a 39.6% increase in the risk of HUA for each quartile increase in PFAS mixtures (WQS index) (OR=1.396,95%CI: 1.180~1.651, P<0.001), and this association was only observed in the female population. n-PFOA and Sm-PFOS were identified as key components, while linear perfluorooctane sulfonic acid (n-PFOS) and perfluorohexane sulfonic acid (PFHxS) may be negatively associated with HUA in the mixture. Potential interactions between various PFAS were also observed. The research findings can provide the latest epidemiological evidence for the study of the association between PFAS exposure and the risk of hyperuricemia, offering a basis for screening key populations.

Key words： hyperuricemia (HUA) PFAS mixtures BKMR WQS

收稿日期: 2024-06-18

PACS:

X503.1

基金资助:辽宁省教育厅科学研究项目(LJKZ0765);辽宁省科学技术计划项目(2021JH4/10200008);沈阳市科学研究项目(23-506-3-01-21)

通讯作者: 刘红波,教授,hbliu@cmu.edu.cn E-mail: hbliu@cmu.edu.cn

作者简介: 冯雨(1998-),男,内蒙古呼和浩特人,硕士研究生,主要从事环境流行病学研究.发表论文1篇.fengyu5859@163.com.

引用本文:

冯雨, 浦少威, 陈祝梅, 朱俊亮, 蔡伟杰, 刘红波. PFAS混合暴露与高尿酸血症关联性研究[J]. 中国环境科学, 2025, 45(1): 322-330. FENG Yu, PU Shao-wei, CHEN Zhu-mei, ZHU Jun-liang, CAI Wei-jie, LIU Hong-bo. Association between perfluoroalkyl and polyfluoroalkyl substances mixture exposure and hyperuricemia. CHINA ENVIRONMENTAL SCIENCECE, 2025, 45(1): 322-330.

链接本文:

http://www.zghjkx.com.cn/CN/ 或 http://www.zghjkx.com.cn/CN/Y2025/V45/I1/322

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