Abstract：50 paired samples of maternal and newborn serum, as well as placenta were collected from pregnant women at delivery around Fuxin fluorochemical facilities, and all the samples were analyzed through the target and non-target screening strategies. In the target analysis, 21 legacy per- and polyfluoroalkyl substances (PFASs) in the whole samples were analyzed through high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), revealing that perfluorobutane sulfonate (PFBS), perfluorobutanoic acid (PFBA), and perfluorooctanoic acid (PFOA) were the dominant PFAS contaminants observed in all the samples. In the suspect screening based upon high-resolution mass spectrometry (HRMS), 49 novel PFASs in 11classes were identified in the Fuxin samples, and 20 novel congeners assigned to 4 classes were determined in human sera and placentas for the first time. In addition, the coefficients for mother-placenta transfer (Rm/p) and mother-newborn transfer (Rm/n) of legacy PFASs could be estimated with the median values of 1.7 and 2.0 individually, and Rm/pand Rm/nof novel PFASs were also calculated with the median values of 0.9 and 0.8, respectively. Accordingly, the average contribution rate of all novel PFASs increased from 90% in maternal serum to 96% in neonatal serum. Moreover, the linear regression analysis determined significant correlations among the neonatal growth parameters (gestation and head circumferences of newborns) and serum levels of thyroid hormone, sex hormone, and glucocorticoid, together with the levels of certain legacy and novel PFASs in neonatal sera, and the most representative compounds included perfluorocarboxylic acids (PFCAs), perfluorosulfonic acids (PFSAs), H-substituted perfluorocarboxylic acids (H-PFCAs), H-substituted perfluorosulfonic acids (H-PFSAs), and chlorinated polyfluorinated ether sulfonates (Cl-PFESAs). The results above demonstrated that legacy and novel PFASs could potentially contribute to certain health risks of newborns.
鲍佳, 渠文娥, 邵立新, 刘洋, 王新, 吴雨晴. 母婴PFASs靶向与非靶向分析及新生儿健康风险[J]. 中国环境科学, 2023, 43(7): 3730-3740.
BAO Jia, QU Wen-e, SHAO Li-xin, LIU Yang, WANG Xin, WU Yu-qing. Target and nontarget analysis of PFASs in mothers and newborns and related health risks of newborns. CHINA ENVIRONMENTAL SCIENCECE, 2023, 43(7): 3730-3740.
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