8:2氟调聚羧酸在虾夷扇贝体内的蓄积、分布与转化

郭萌萌; 国佼; 李风铃; 王智; 刘晓玉; 翟毓秀; 谭志军

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中国环境科学 ›› 2020, Vol. 40 ›› Issue (10) : 4607-4616.

环境毒理

8:2氟调聚羧酸在虾夷扇贝体内的蓄积、分布与转化

郭萌萌¹, 国佼², 李风铃¹, 王智³, 刘晓玉¹, 翟毓秀¹, 谭志军¹

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Uptake, distribution and biotransformation of 8:2 fluorotelomer carboxylic acid (8: 2FTCA) in scallops (Patinopecten yessoensis)

GUO Meng-meng¹, GUO Jiao², LI Feng-ling¹, WANG Zhi³, LIU Xiao-yu¹, ZHAI Yu-xiu¹, TAN Zhi-jun¹

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摘要

以虾夷扇贝（Patinopecten yessoensis）为受试生物，研究了8：2氟调聚羧酸（8：2FTCA）在虾夷扇贝不同组织（肝脏、鳃、性腺、外套膜、闭壳肌）中的蓄积、分布和生物转化特征.结果显示，8：2FTCA蓄积浓度最高的组织为肝脏，达峰值最快的组织为鳃.在8：2FTCA代谢过程中，检测到8：2氟调聚不饱和酸（8：2FTUCA）、7：3氟调聚羧酸（7：3FTCA）、全氟辛酸（PFOA）、全氟壬酸（PFNA）和全氟庚酸（PFHpA）5种代谢产物，其中7：3FTCA和PFOA为含量最丰富的2种代谢产物.它们主要分布在鳃和肝脏组织中，鳃和肝脏是8：2FTCA进行生物转化的主要器官，并且鳃组织中代谢产物的浓度最高.推测出虾夷扇贝体内8：2FTCA的生物转化路径，与虹鳟的生物转化行为相比，虾夷扇贝在代谢产物产量和半衰期上均有差异，说明水生生物的生物转化行为具有物种差异性.8：2FTCA在虾夷扇贝体内可转化为PFOA、PFNA和PFHpA等全氟烷基羧酸（PFCAs），是虾夷扇贝体内PFCAs的一个间接来源.

Abstract

The uptake, tissue distribution and biotransformation of 8:2fluorotelomer carboxylic acid (8:2FTCA) in liver, gills, sexual gland, mantle and adductor muscle tissues of the scallop Patinopecten yessoensis were investigated. The highest concentration of 8:2 FTCA was detected in the liver, and the maximum uptake rate of 8:2 FTCA in the gills. Five metabolic products, including 8:2 fluorotelomer unsaturated carboxylic acid (8:2 FTUCA), 7:3 fluorotelomer carboxylic acid (7:3 FTCA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluoroheptanoic acid (PFHpA) were identified in scallops. 7:3 FTCA and PFOA were major metabolites, which tended to accumulate in gills and liver. The biotransformation of parent compound 8:2 FTCA was dominantly occurred in gills, where the metabolites were present at the highest concentrations. The biotransformation pathway of 8:2 FTCA in P. yessoensis was proposed for the first time. Compared with the biotransformation behavior of 8:2 FTCA in rainbow trout, the distinct species differences were observed in the yield and half-life of metabolites in P. yessoensis. These results indicated that 8:2 FTCA can be easily transformed in P. yessoensis, and the detection of PFOA, PFNA and PFHpA indicates that exposure to 8:2 FTCA may be an indirect route of exposure to PFCAs in scallops.

导出引用

郭萌萌, 国佼, 李风铃, 王智, 刘晓玉, 翟毓秀, 谭志军. 8:2氟调聚羧酸在虾夷扇贝体内的蓄积、分布与转化[J]. 中国环境科学. 2020, 40(10): 4607-4616

GUO Meng-meng, GUO Jiao, LI Feng-ling, WANG Zhi, LIU Xiao-yu, ZHAI Yu-xiu, TAN Zhi-jun. Uptake, distribution and biotransformation of 8:2 fluorotelomer carboxylic acid (8: 2FTCA) in scallops (Patinopecten yessoensis)[J]. China Environmental Science. 2020, 40(10): 4607-4616

中图分类号： X174

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