Accumulation, distribution and elimination of perfluorooctanoic acid (PFOA) in mussels (Mytilus galloprpvincialis)
CUI Wen-jie1,2, LIU Xiao-yu1,3, SUN Xiao-jie1, TAN Zhi-jun1, LI Zhao-xin1, GUO Meng-meng1, ZHAI Yu-xiu1
1. Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; 2. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; 3. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
Abstract：The accumulation characteristics, tissue distributions and elimination pathways of perfluorooctanoic acid (PFOA) in the mussels (Mytilus galloprpvincialis) were investigated. PFOA could be accumulated rapidly by the mussels, leading to the whole-body mussels reached steady-state after 4~6d exposure to different target concentrations. The half-lives of the whole-body mussel were 0.34~0.44d (about 8~10h) with the bioconcentration factors (BCFs) ranged from 5.10 to 9.55mL/g. PFOA tended to accumulate in gills and visceral mass. The concentrations of PFOA in mussels tended to be blank level after 6~9d of depuration and the main elimination pathway may by the gills. Moreover, the bioconcentration effect of PFOA in Mytilus galloprpvincialis was related to the exposure concentrations.
崔文杰, 刘晓玉, 孙晓杰, 谭志军, 李兆新, 郭萌萌, 翟毓秀. 全氟辛酸在紫贻贝体内的富集、分布与消除[J]. 中国环境科学, 2020, 40(9): 4091-4098.
CUI Wen-jie, LIU Xiao-yu, SUN Xiao-jie, TAN Zhi-jun, LI Zhao-xin, GUO Meng-meng, ZHAI Yu-xiu. Accumulation, distribution and elimination of perfluorooctanoic acid (PFOA) in mussels (Mytilus galloprpvincialis). CHINA ENVIRONMENTAL SCIENCECE, 2020, 40(9): 4091-4098.
Rand A A, Rooney J P, Butt C M, et al. Cellular toxicity associated with exposure to perfluorinated carboxylates (PFCAs) and their metabolic precursors[J]. Chemical Research in Toxicology, 2014, 27(1):42-50.
Mazzoni M, Buffo A, Cappelli F, et al. Perfluoroalkyl acids in fish of Italian deep lakes:Environmental and human risk assessment[J]. Science of the Total Environment, 2019,653:351-358.
Houde M, De Silva AO, Muir D C G, et al. Monitoring of perfluorinated compounds in aquatic biota:an updated review[J]. Environmental Science & Technology, 2011,45(19):7962-7973.
Vassiliadou I, Costopoulou D, Kalogeropoulos N, et al. Levels of perfluorinated compounds in raw and cooked Mediterranean finfish and shellfish[J]. Chemosphere, 2015,127:117-126.
Martin J, Hidalgo F, Garcia-Corcoles M T, et al. Bioaccumulation of perfluoroalkyl substances in marine echinoderms:Results of laboratory-scale experiments with Holothuria tubulosa Gmelin, 1791[J]. Chemosphere, 2019,215:261-271.
Sunderland E M, Hu X C, Dassuncao C, et al. A review of the pathways of human exposure to poly-and perfluoroalkyl substances (PFASs) and present understanding of health effects[J]. Journal of Exposure Science & Environmental Epidemiology, 2019,29(2):131-147.
Cai M H, Zhao Z, Yang H Z, et al. Spatial distribution of per-and polyfluoroalkyl compounds in coastal waters from the East to South China Sea[J]. Environmental Science & Technology, 2012,161:162-169.
Wang P, Lu Y L, Wang T Y, et al. Occurrence and transport of 17perfluoroalkyl acids in 12coastal rivers in south Bohai coastal region of China with concentrated fluoropolymer facilities[J]. Environmental Pollution, 2014,190:115-122.
崔文杰,彭吉星,谭志军,等.全氟烷基物质在胶州湾海水、沉积物及生物中污染特征[J]. 环境科学, 2019,40(9):3990-3999. Cui W J, Peng J X, Tan Z J, et al. Pollution characteristics of perfluorinated alkyl substances (PFASs) in seawater, sediments and biological samples from Jiaozhou Bay, China[J]. Environmental Science, 2019,40(9):3990-3999.
Liu C H, Gin K Y H, Chang V W C, et al. Novel perspectives on the bioaccumulation of PFCs-the concentration dependency[J]. Environmental Science & Technology, 2011,45(22):9758-9764.
Kibria G, Hossain M M, Mallick D, et al. Monitoring of metal pollution in waterways across Bangladesh and ecological and public health implications of pollution[J]. Chemosphere, 2016,165:1-9.
Nakata H, Kannan K, Nasu T, et al. Perfluorinated contaminants in sediments and aquatic organisms collected from shallow water and tidal flat areas of the Ariake Sea, Japan:environmental fate of perfluorooctane sulfonate in aquatic ecosystems[J]. Environmental Science & Technology, 2006,40(16):4916-4921.
张明,唐访良,俞雅雲,等.钱塘江(杭州段)表层水中全氟化合物的残留水平及分布特征[J]. 环境科学, 2015,36(12):4471-4478. Zhang M, Tang F L, Yu Y Y, et al. Residue concentration and distribution characteristics of perfluorinated compounds in surface water from Qiantang river in Hangzhou section[J]. Environmental Science, 2015,36(12):4471-4478.
郭萌萌,吴海燕,卢立娜,等.杂质延迟-液相色谱-四极杆/离子阱复合质谱测定水产加工食品中23种全氟烷基化合物[J]. 分析化学, 2015,43(8):1105-1112. Guo M M, Wu H Y, Lu L N, et al. Simultaneous identification and detection of 23perfluorinated alkyl substances in processed aquatic products by impurity delay using liquid chromatography coupled with quadrupole/linear ion trap mass spectrometry[J]. Chinese Journal of Analytical Chemistry, 2015,43(8):1105-1112.
Liu J C, Lu G H, Yang H H, et al. Bioconcentration and metabolism of ketoconazole and effects on multi-biomarkers in crucian carp (Carassius auratus)[J]. Chemosphere, 2016,150:145-151.
Wen W, Xia X H, Zhou D, et al. Bioconcentration and tissue distribution of shorter and longer chain perfluoroalkyl acids (PFAAs) in zebrafish (Danio rerio):effects of perfluorinated carbon chain length and zebrafish protein content[J]. Environmental Pollution, 2019,249:277-285.
Shi Y L, Vestergren R, Nost T H, et al. Probing the differential tissue distribution and bioaccumulation behavior of per-and polyfluoroalkyl substances of varying chain-lengths, isomeric structures and functional groups in Crucian Carp[J]. Environmental Science & Technology, 2018,52(8):4592-4600.
Falk S, Failing K, Georgii S, et al. Tissue specific uptake and elimination of perfluoroalkyl acids (PFAAs) in adult rainbow trout (Oncorhynchus mykiss) after dietary exposure[J]. Chemosphere, 2015,129:150-156.
Jing W X, Lang L, Lin Z G, et al. Cadmium bioaccumulation and elimination in tissues of the freshwater mussel Anodonta woodiana[J]. Chemosphere, 2019,219:321-327.
Ng C A, Hungerbühler K. Bioconcentration of perfluorinated alkyl acids:how important is specific binding?[J]. Environmental Science& Technology, 2013,47(13):7214-7223.
Zhang B, Shi Z R, Wang X L, et al. Depuration of cadmium from blue mussel (Mytilus edulis) by hydrolysis peptides and chelating metal elements[J]. Food Research International, 2015,73:162-168.
Ulhaq M, Sundström M, Larsson P, et al. Tissue uptake, distribution and elimination of 14C-PFOA in zebrafish (Danio rerio)[J]. Aquatic Toxicology, 2015,163:148-157.
Martin J W, Mabury S A, Solomon K R, et al. Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)[J]. Environmental Toxicology and Chemistry, 2003,22(1):196-204.
Lee J J, Schultz I R. Sex differences in the uptake and disposition of perfluorooctanoic acid in fathead minnows after oral dosing[J]. Environmental Science & Technology, 2010,44(1):491-496.
Hundley S G, Sarrif A M, Kennedy G L. Absorption, distribution, and excretion of ammonium perfluorooctanoate (PFOA) after oral administration to various species[J]. Drug and Chemical Toxicology, 2006,29(2):137-45.
Han X, Snow T A, Kemper R A, et al. Binding of perfluorooctanoic acid to rat and human plasma proteins[J]. Chemical Research in Toxicology, 2003,16(6):775-781.
Butenhoff J L, Kennedy J G L, Hinderliter P M, et al. Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys[J]. Toxicological sciences, 2004,82(2):394-406.
Andersen M E, Butenhoff J L, Chang S C, et al. Perfluoroalkyl acids and related chemistries-toxicokinetics and modes of action[J]. Toxicological sciences, 2008,102(1):3-14.
Kudo N, Kawashima Y. Induction of triglyceride accumulation in the liver of rats by perfluorinated fatty acids with different carbon chain lengths:comparison with induction of peroxisomal β-oxidation[J]. Biological & Pharmaceutical Bulletin, 2003,26(1):47-51.
Morikawa A, Kamei N, Harada K, et al. The bioconcentration factor of perfluorooctane sulfonate is significantly larger than that of perfluorooctanoate in wild turtles (Trachemys scripta elegans and Chinemys reevesii):an Ai river ecological study in Japan[J]. Ecotoxicology and Environmental Safety, 2006,65(1):14-21.
Conder J M, Hoke R A, Wolf W D, et al. Are PFCAs bioaccumulative? A critical review and comparison with regulatory criteria and persistent lipophilic compounds[J]. Environmental Science & Technology, 2008,42(4):995-1003.
马佳乐,侯萍,王思瑶,等.全氟辛酸诱导斑马鱼脾脏损伤及白细胞介素表达紊乱的免疫毒效应研究[J]. 环境科学学报, 2016,36(7):2687-2693. Ma J L, Hou P, Wang S Y, et al. Damage and interleukins expression disorders of zebrafish spleen induced by perfluorooctanoic acid (PFOA) in vivo[J]. Acta Scientiae Circumstantiae, 2016,36(7):2687-2693.
杜桂珍.全氟化合物PFOA、PFOS内分泌干扰效应的研究[D]. 南京:南京医科大学, 2013. Du G Z. Studies on the endocrine-disrupting effects of PFOA and PFOS[D]. Nanjing:Nanjing Medical University, 2013.
Zhong W J, Zhang L Y, Cui Y N, et al. Probing mechanisms for bioaccumulation of perfluoroalkyl acids in carp (Cyprinus carpio):impacts of protein binding affinities and elimination pathways[J]. Science of the Total Environment, 2019,647:992-999.
Gobas F A, Opperhuizen A. Bioconcentration of hydrophobic chemicals in fish:Relationship with membrane permeation[J]. Environental Toxicology and Chemistry, 1986,5:637-646.
Chen F F, Gong Z Y, Kelly B C. Bioavailability and bioconcentration potential of perfluoroalkyl-phosphinic and -phosphonic acids in zebrafish (Danio rerio):Comparison to perfluorocarboxylates and perfluorosulfonates[J]. Science of the Total Environment, 2016,568:33-41.
Hundley S G,Sarrif A M,Kennedy G L. Absorption, distribution, and excretion of ammonium perfluorooctanoate (PFOA) after oral administration to various species[J]. Drug and Chemical Toxicology, 2006,29(2):137-45.